Purification of leukocytosis-promoting substance from bovine parotid gland extract |
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Authors: | Masato Shinoda Shizuo Nakajin Takayuki Oikawa Motoyuki Shimizu Asahi Kamogawa |
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Institution: | Department of Biochemistry, Hoshi College of Pharmacy, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142, Japan |
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Abstract: | A leukocytosis-promoting substance was purified from a crude bovine parotid gland extract. The purified substance was proved to be a single component by polyacrylamide gel disc electrophoresis. It stimulates an increase of peripheral leukocyte numbers in rabbits. The molecular weight of the physiologically active component was estimated to be 4.5 · 104, and the component was found by sodium dodecyl sulfate polyacrylamide gel electrophoresis to be dissociated into two subcomponents. |
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Keywords: | Leukocytosis-promoting substance (Bovine parotid gland) |
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