Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide |
| |
Authors: | Gerd P Bienert François Chaumont |
| |
Institution: | 1. Leibniz Institute of Plant Genetics and Crop Plant Research, Corrensstrasse 3, 06466 Gatersleben, Germany;2. Institut des Sciences de la Vie, Université catholique de Louvain, Croix du Sud 4-L7.07.14, 1348 Louvain-la-Neuve, Belgium |
| |
Abstract: | BackgroundHydrogen peroxide (H2O2) is an important signaling compound that has recently been identified as a new substrate for several members of the aquaporin superfamily in various organisms. Evidence is emerging about the physiological significance of aquaporin-facilitated H2O2 diffusion.Scope of reviewThis review summarizes current knowledge about aquaporin-facilitated H2O2 diffusion across cellular membranes. It focuses on physicochemical and experimental evidence demonstrating the involvement of aquaporins in the transport of this redox signaling compound and discusses the regulation and structural prerequisites of these channels to transmit this signal. It also provides perspectives about the potential importance of aquaporin-facilitated H2O2 diffusion processes and places this knowledge in the context of the current understanding of transmembrane redox signaling processes.Major conclusionsSpecific aquaporin isoforms facilitate the passive diffusion of H2O2 across biological membranes and control H2O2 membrane permeability and signaling in living organisms.General significanceRedox signaling is a very important process regulating the physiology of cells and organisms in a similar way to the well-characterized hormonal and calcium signaling pathways. Efficient transmembrane diffusion of H2O2, a key molecule in the redox signaling network, requires aquaporins and makes these channels important players in this signaling process. Channel-mediated membrane transport allows the fine adjustment of H2O2 levels in the cytoplasm, intracellular organelles, the apoplast, and the extracellular space, which are essential for it to function as a signal molecule. This article is part of a Special Issue entitled Aquaporins. |
| |
Keywords: | AQP aquaporin ASMC aortic smooth muscle cells CM-H2DCFDA (5-(and-6)-chloromethyl-2 7-dichlorodihydrofluorescein diacetate acetyl ester EGF epidermal growth factor GLP glycerol facilitator-like protein HDCFDA 2&prime 7&prime -dichlorodihydrofluorescein diacetate HEK 293 human embryonic kidney 293 H2O2 hydrogen peroxide MIP major intrinsic protein NIP nodulin26-like intrinsic protein PIP plasma membrane intrinsic protein PY1-ME peroxy yellow 1 methyl ester ROS reactive oxygen species TIP tonoplast intrinsic protein XIP X intrinsic protein |
本文献已被 ScienceDirect 等数据库收录! |
|