A potential antioxidant resource: Endophytic fungi from medicinal plants |
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Authors: | Wu-Yang Huang Yi-Zhong Cai Jie Xing Harold Corke Mei Sun |
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Institution: | (1) Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China;(2) Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China;(3) Republic Polytechnic, Woodlands Avenue 9, 738964 Singapore |
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Abstract: | Medicinal plants and their endophytes are important resources for discovery of natural products. Several previous studies
have found a positive correlation between total antioxidant capacity (TAC) and total phenolic content (TPC) of many medicinal
plant extracts. However, no information is available on whether such a relationship also exists in their endophytic fungal
metabolites. We investigated the relationship between TAC and TPC for 292 morphologically distinct endophytic fungi isolated
from 29 traditional Chinese medicinal plants. The antioxidant capacities of the endophytic fungal cultures were significantly
correlated with their total phenolic contents, suggesting that phenolics were also the major antioxidant constituents of the
endophytes. Some of the endophytes were found to produce metabolites possessing strong antioxidant activities. Several bioactive
constituents from the fungal cultures and host plant extracts were identified. This investigation reveals that the metabolites
produced by a wide diversity of endophytic fungi in culture can be a potential source of novel natural antioxidants. |
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Keywords: | Endophytic fungi metabolites medicinal plants antioxidant activity phenolic compounds Chinese medicinal plants traditional Chinese medicine TCM |
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