| 天然水蛭素冻干粉实验结果的分析 |
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| 引用本文： | 苏承武,周维官,周维海,李小平,殷国前,丘毅,江传福,贺彬.天然水蛭素冻干粉实验结果的分析[J].蛇志,2010,22(4):336-338. |
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| 作者姓名： | 苏承武 周维官 周维海 李小平 殷国前 丘毅 江传福 贺彬 |
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| 作者单位： | [1]广西医科大学,广西南宁530021 [2]广西天然水蛭素生物科技有限公司,广西南宁530007 [3]广西科康天然水蛭素研究院,广西南宁530007 |
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| 基金项目： | 广西科技厅科技攻关与新产品试制项目资助 |
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| 摘 要： | 目的研究天然水蛭素冻干粉的生物化学成分及其毒理学的安全性。方法采用《中华人民共和国药典》的抗凝血酶活性测定法、电感耦合等离子体质谱法、《中华人民共和国国家标准》中的食品中水分、微生物、重金属检测、检验法等。结果天然水蛭素具有较高的抗凝血酶活性(809 ATU/g),无致病菌,微生物及重金属不超标,对动物和人体无毒副作用。结论天然水蛭素有潜在的药物开发价值。
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| 关 键 词： | 菲牛蛭 天然水蛭素 毒理学 安全性 |
Analysis of experimental results of natural freeze-dried hirudin powder from manillensis |
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| SU Cheng-wu,ZHOU Wei-guan,ZHOU Wei-hai,LI Xiao-ping,YIN Guo-qian,QIU Yi,JIANG Chuan-fu,HE Bin.Analysis of experimental results of natural freeze-dried hirudin powder from manillensis[J].Journal of Snake,2010,22(4):336-338. |
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| Authors: | SU Cheng-wu ZHOU Wei-guan ZHOU Wei-hai LI Xiao-ping YIN Guo-qian QIU Yi JIANG Chuan-fu HE Bin |
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| Institution: | 1.Guangxi Medical University,Nanning,Guangxi,530021,China;2.Guangxi Natural Hirudin Biotechnology Co.,Ltd.,Nanning,Guangxi,530007,China;3.Guangxi Keyken Natural Hirudin Institute,Nanning,Guangxi,530007,China) |
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| Abstract: | Objective To study the biochemical composition and toxicological safety of freeze-dried hirudin powder of Philippine manillensis.Methods According to inductively coupled plasma mass spectrometry of ＂Chinese Pharmacopoeia＂ and ＂Test method of water,microbes and heavy metals in food＂ and ＂Determination of antithrombin activity＂.Results Natural hirudin from manillensis has a higher antithrombin activity（809 ATU/g）,it is without pathogenic bacteria,excessive micro-organisms,heavy metals and toxic side effects on animals and humans.Conclusion Natural hirudin form manillensis has great potential value for drug exploition. |
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| Keywords: | Hirudinaria manillensis Lesson hirudin Toxicology safety |
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