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| 广西眼镜蛇毒L-氨基酸氧化酶体内外抗血小板聚集实验研究 | |
| 引用本文： | 王辉,黎肇炎,黄江南.广西眼镜蛇毒L-氨基酸氧化酶体内外抗血小板聚集实验研究[J].蛇志,2008,20(2):91-93. |
| 作者姓名： | 王辉 黎肇炎 黄江南 |
| 作者单位： | 1. 广西医科大学药学院,广西南宁,530021 2. 广西医科大学蛇毒研究所,广西南宁,530021 3. 广西医科大学一附院,广西南宁,530021 |
| 摘 要： | 目的 研究广西眼镜蛇中提取的L-氨基酸氧化酶(L-amino acid oxidase)在人体外及家兔体内的抗血小板聚集作用.方法 用比浊法测定广西眼镜蛇毒L-氨基酸氧化酶对二磷酸腺苷(ADP)、胶原、凝血酶、花生四烯酸(AA)在人体外及家兔体内引起的血小板聚集率的影响.结果 实验中,能明显抑制二磷酸腺苷(ADP)、胶原、凝血酶、花生四烯酸(AA)引起的血小板聚集,并呈明显的正相关.结论 广西眼镜蛇毒L-氨基酸氧化酶在体内外均有较强的抗血小板聚集活性. |
| 关 键 词： | 广西眼镜蛇毒 L-氨基酸氧化酶 血小板聚集 广西 眼镜蛇毒 氨基酸 氧化酶 体内外 血小 聚集活性 实验 研究 in vivo platelet rabbit in vitro human venom cobra Guangxi acid effect 相关 |
The antiplatelet effect of L-amino acid oxidase from Guangxi cobra venom on human platelet in vitro and rabbit platelet in vivo |
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| WANG Hui,LI Zhao-yan,HUANG Jiang-nan.The antiplatelet effect of L-amino acid oxidase from Guangxi cobra venom on human platelet in vitro and rabbit platelet in vivo[J].Journal of Snake,2008,20(2):91-93. | |
| Authors: | WANG Hui LI Zhao-yan HUANG Jiang-nan |
| Institution: | WANG Hui1,LI Zhao-yan2,HUANG Jiang-nan3(1.School of Pharmaceutical Sciences Guangxi Medical University,Nanning,Guangxi,530021,China,2.Snake Venom Reseach Znstitute of Guangxi Medical University,3.The Fivst Affiliated Hospital of Guangxi Medical University,China) |
| Abstract: | Objective To study the antiaggregationg effect of L-amino acid oxidase(LAAO)purified from Guangxi cobra venom on human and rabbit platelet aggregation.Methods LAAO effects on the platelet aggregation induced by ADP,thrombin,collagen and AA was measured by turbidinmetric method on human and rabbit platelet aggregation in vitro and in vivo.Results LAAO could inhibit the activity of platelet aggregation induced by ADP,thrombin,collagen and AA.Conclusion LAAO can inhibit the activity of platelet aggregation in ... |
| Keywords: | Guangxi Cobra Venom L-amino acid oxidase platelet aggregation |
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