灯盏花素粉针剂在不同pH值溶媒中的稳定性观察

目的观察灯盏花素粉针剂在不同pH值溶液中的稳定性。方法在室温(20℃)下,将5%、10%葡萄糖注射液及0.9%氯化钠注射液的pH值调整为3.3、3.6、3.9、4.2后,再分别加入灯盏花素粉针剂,并采用紫外分光光度法在6 h内的不同时间取样测定其含量。结果灯盏花素粉针剂在溶液pH值为3.3时,含量下降很快;pH值为3.6、3.9时,含量下降变缓;pH值为4.2时,含量趋于稳定,无明显变化。结论影响灯盏花素粉针剂稳定性的主要因素是稀释溶媒的pH值。当pH值在3.3~3.6时,灯盏花素易产生浑浊沉淀现象,故建议临床不用葡萄糖注射液作灯盏花素粉针剂的稀释溶媒为好。

Injection Steadying Investigation of Shortscape Fleabane Herb's pollen in different pH Solvent

Objective To investigate injection steadying of shortscape fleabane herb＇s pollen in different pH infusion. Methods At indoor temperature （20℃） ,adjusted pH of 5% GS,10% GS and 0.9%NS to 3.3,3.6,3.9,4.2,then mixed injection of shortscape fleabane herb＇s pollen,used UV-spectrophotometry to determinate content at different time of them in 6 h. Results Content of injection of shortseape fleabane herb＇s pollen rapid decline at pH 3.3;content decline become slow at pH 3. 6 and 3. 9; content decline become basic steady at pH 4.2, no change clearly. Conclusion Main factor of influence content of shortscape fleabane herb＇s pollen is dilution solvent＇s pH. Because when pH in 3.3-3.6, shortscape fleabane herb＇s pollen become muddy sediment easily,so recommending don＇t use grape sugar solution to injection of shortscape fleabane herb＇s pollen.