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蕲蛇酶抗栓作用机理的初步分析
引用本文:王晴川,刘广芬.蕲蛇酶抗栓作用机理的初步分析[J].蛇志,1997,9(3):9-11.
作者姓名:王晴川  刘广芬
作者单位:福建医科大学蛇毒研究所
摘    要:动物实验结果示,蕲蛇酶能裂解纤维蛋白原成为可溶性纤维蛋白,降低血中纤维蛋白原浓度,抑制血小板聚集,对抗在酶诱导的血浆凝块订的血浆凝块回缩,因而发挥防血栓形成作用。对纤维蛋白平板试验无直接溶纤作用,但能增加实验动物血中t-PA活性。可能通过促使血管内皮细胞释放t-PA而发挥溶栓作用。

关 键 词:蕲蛇酶  凝血酶样酶  血栓溶解  药理学  血栓形成

A preliminary analysis of the Antithrombotic mechanism Agkistrodon acutus enzyme
Wang Qingchuan Xu Yunlu Liu Guangfen Laboratory of Venom Research,Fujian Medical University,Fuzhou.A preliminary analysis of the Antithrombotic mechanism Agkistrodon acutus enzyme[J].Journal of Snake,1997,9(3):9-11.
Authors:Wang Qingchuan Xu Yunlu Liu Guangfen Laboratory of Venom Research  Fujian Medical University  Fuzhou
Institution:Wang Qingchuan Xu Yunlu Liu Guangfen Laboratory of Venom Research,Fujian Medical University,Fuzhou,350004
Abstract:The results of animal experiments show that Agkistrodon acutus enzyme can lower the fibrinogen level in blood plasma by converting fibrinogen into soluble fibrin,and inhibit platelet aggregation and plasm clot retraction induced by thrombin, there by preventing thrombi formation The enzyme does not exhibit direct fibrinolytic effect in the fibrin plate assay, but increases the t-PA activity in the blood Hence, the thrombolytic effect of the enzyme may be due to the promotion of t-PA release from the endothelium
Keywords:Agkistrodon acutus enjyme  Snake venom    thrombin-like enzyme  animal experiment
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