| 花椒总生物碱镇痛、抗炎、止痒作用研究 |
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| 引用本文： | 石雪萍,张卫明,张鸣镝,关荣琴.花椒总生物碱镇痛、抗炎、止痒作用研究[J].中国野生植物资源,2011,30(1):46-49. |
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| 作者姓名： | 石雪萍 张卫明 张鸣镝 关荣琴 |
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| 作者单位： | 1. 南京野生植物综合利用研究院,江苏,南京,210042
2. 吉林大学军需科技学院,吉林,长春,130062 |
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| 基金项目： | 国家"十一五"科技支撑计划重点课题 |
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| 摘 要： | 目的:研究花椒生物碱镇痛、抗炎及止痒作用。方法:分别采用热板法考察其镇痛作用二甲苯致炎法考察其抗炎作用、低分子右旋糖酐-40诱发小鼠皮肤瘙痒研究其止痒作用。结果:中、高浓度的花椒生物碱对小鼠热刺激引起的疼痛具有较强的镇痛作用;高浓度的花椒生物碱能较强抑制二甲苯所致小鼠耳肿胀,并能缓解分子右旋糖酐-40诱发的小鼠皮肤瘙痒。具有较强的抗炎、止痒作用。结论:花椒生物碱具有较强的镇痛、抗炎、止痒作用。
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| 关 键 词： | 花椒 生物碱 镇痛 抗炎 止痒 |
Analgesic, Anti- inflammatory and Antipruritic Effects of Zanthoxylum Alkaloids |
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| Shi Xueping,Zhang Weiming,Zhang Mingdi,Guan Rongqin.Analgesic, Anti- inflammatory and Antipruritic Effects of Zanthoxylum Alkaloids[J].Chinese Wild Plant Resources,2011,30(1):46-49. |
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| Authors: | Shi Xueping Zhang Weiming Zhang Mingdi Guan Rongqin |
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| Institution: | Shi Xueping1,Zhang Weiming1,Zhang Mingdi2,Guan Rongqin2(1.Nanjing Institute for Comprehensive Utilization of Wild Plant,Nanjing 210042,China,2.College of Quartermaster Technology,Jilin University,Changchun 130062,China) |
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| Abstract: | Objective： To study the analgesic anti -inflammatory, and antipruritic efects of Zanthoxylum alkaloids. Methods ： The 55 ℃ hot plate test in mice were used to detect the analgesia. The anti - inflam- matory effects were detected with xylene - induced ear swelling and carrageenan hind paws edema in mice and the itch - scratch responses were induced by IV dextran - 40 in mice. Results ： The Zanthoxylum alkaloids raised mouse pain threshold in high and middle dose manner. The Zanthoxylum alkaloids inhibited mouse ears edema significantly in a dose - dependent manner. Zanthoxylum alkaloids also significantly decreased paroxysm frequency and the duration of the itch. Conclusions ： The Zanthoxylum alkaloids possess analgetic anti- inflammatory, and antipruritic effects. |
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| Keywords: | Zanthoxylum alkaloids analgesics anti-inflammatory antipruritics |
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