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丁香苷抗炎镇痛作用及部分机制研究
引用本文:宋媛媛,李媛,张洪泉.丁香苷抗炎镇痛作用及部分机制研究[J].中国野生植物资源,2010,29(4):27-30,41.
作者姓名:宋媛媛  李媛  张洪泉
作者单位:扬州大学医药研究所,江苏,扬州,225001
摘    要:研究丁香苷抗炎镇痛作用及部分机制。以阿司匹林作阳性对照药,观察丁香苷对二甲苯致小鼠耳廓肿胀、醋酸致小鼠毛细血管通透性增加、角叉菜胶致大鼠足趾肿胀、棉球致大鼠肉芽肿的抗炎作用;对小鼠热板试验、醋酸扭体试验的镇痛作用;同时测定角叉菜胶致大鼠炎足炎性渗出物中的PGE2、MDA和血清中的NO、SOD,初步探讨丁香苷抗炎镇痛的部分机制。结果表明,丁香苷对急慢性炎症反应有明显抑制作用,能明显降低角叉菜胶致炎足炎性渗出物中PGE2、MDA和血清中NO含量,明显增加血清中SOD的活性。因此,丁香苷具有较强的抗炎镇痛作用,其机制可能与抑制PGE2、NO等炎症介质生成、增强自由基清除能力有关。

关 键 词:丁香苷  抗炎  镇痛  作用机制

Anti-inflammatory and Analgesic Activity of Syringin and Its Possible Mechanism
Song Yuanyuan,Li Yuan,Zhang Hongquan.Anti-inflammatory and Analgesic Activity of Syringin and Its Possible Mechanism[J].Chinese Wild Plant Resources,2010,29(4):27-30,41.
Authors:Song Yuanyuan  Li Yuan  Zhang Hongquan
Institution:(Medical and Pharmaceutical Institute, Yangzhou University, Yangzhou 225001, China)
Abstract:To study the anti - inflammatory and anti - nociceptive activities of Syringin and its possible mechanism. To study the anti -inflammatory and anti -nocieeptive activities on inflammatory models in mice and rats with positive drug of aspirin. The anti - inflammatory mechanism of Syringin was observed by assessing the changes of the levels of the PGE2, MDA in the inflammatory tissues of the rat paw inflammation model induced by carregenin and the changes of the levels of NO, SOD in blood serum. The results showed that Syringin produced a prominent inhibitory effect on inflammatory models. Syringin re- duced the levels of the PGE2, MDA in the inflammatory tissues of the rat paw edema model, reduced the levels of the NO in blood serum and increased the activity of the SOD in blood serum. These results reveal that Syringin has an obvious anti -inflammatory effect. Its primary action is related to the reduction of the levels of PGE2, NO and increase of SOD activity in blood serum.
Keywords:Syringin  Anti - inflammatory  anti - nociceptive  Mechanism
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