| 熊果酸抗肿瘤和抗心血管疾病作用的研究进展 |
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| 引用本文： | 向敏,王建梅,凌婧,徐晓月.熊果酸抗肿瘤和抗心血管疾病作用的研究进展[J].中国野生植物资源,2009,28(6):7-10,14. |
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| 作者姓名： | 向敏 王建梅 凌婧 徐晓月 |
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| 作者单位： | 1. 苏州卫生职业技术学院,江苏,苏州,215009
2. 河南省食品药品检验所,药理室,河南,郑州,450003 |
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| 基金项目： | 江苏省卫生科研计划项目 |
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| 摘 要： | 熊果酸（ursolic cid，UA）属三萜类化合物，是许多中药复方的主要有效成分之一。它具有抗肿瘤、抗糖尿病、降脂、抗炎、抗氧化等多种生物学效应。本文就UA对肿瘤细胞增殖信号通路的影响和抗心血管疾病作用研究进展方面进行综述，以期为UA的开发提供新思路。
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| 关 键 词： | 熊果酸 肿瘤细胞增殖 信号通路 心血管疾病 |
The Research Advances of Ursolic Acid on Anti - cancer and Anti - vascular Disease Effect |
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| Institution: | Xiang Min, Wang Jianmei , Ling Jing, Xu Xiaoyue (1. Suzhou Health College, Suzhou 215009, China; 2. Pharmacology Department, Food and Drug Inspection Institute of Henan Province, Zhengzhou 450003, China) |
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| Abstract: | Ursolic Acid（ UA）, one of pentacyclic triterpenes compounds, distributes in many plants and the major active component in these herbal medicine. UA shows several bioactivities, such as anti - tumor, anti - diabetic, lowering hyperlipemia, anti - inflammation, and antioxidant activities, et al. This article reviews effects of UA on cancer cell proliferation signal transduction pathway and anti - vascular disease in order to provide some new ideas on the development of UA. |
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| Keywords: | Ursolic acid cancer cell proliferation signal transduction pathway vascular diseases |
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