| 靶向纳米探针介导的近红外激光热疗 |
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| 引用本文： | 周非凡,宋盛,吴宝艳,欧忠敏,邢达.靶向纳米探针介导的近红外激光热疗[J].激光生物学报,2011,20(1):125-129. |
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| 作者姓名： | 周非凡 宋盛 吴宝艳 欧忠敏 邢达 |
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| 作者单位： | 华南师范大学生物光子学研究院激光生命科学研究所、暨激光生命科学教育部重点实验室,广东,广州,510631 |
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| 基金项目： | 科技部国家重点基础研究973计划项目，教育部"长江学者与创新团队计划"创新团队项目，国家自然科学基金 |
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| 摘 要： | 肿瘤靶向治疗的研究是当今生物医学界的研究热点.本研究采用整合素αvβ3单克隆抗体作为肿瘤靶向分子,以单壁碳纳米管(SWNT)作为运输载体,同时利用单壁碳纳米管在近红外区的光吸收特性,开展靶向肿瘤光热治疗.实验结果表明,这种整合素αvβ3单抗标记的碳纳米管探针对高表达αvβ3的U87MG细胞具有高靶向选择性和靶向光杀伤性...
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| 关 键 词： | 肿瘤靶向治疗 碳纳米管 光热治疗 靶向探针 |
Near-infrared Region Photothermal Therapy using Targeting Nanoprobe |
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| ZHOU Fei-fan,SONG Sheng,WU Bao-yan,OU Zhong-min,XING Da.Near-infrared Region Photothermal Therapy using Targeting Nanoprobe[J].ACTA Laser Biology Sinica,2011,20(1):125-129. |
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| Authors: | ZHOU Fei-fan SONG Sheng WU Bao-yan OU Zhong-min XING Da |
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| Institution: | ZHOU Fei-fan,SONG Sheng,WU Bao-yan,OU Zhong-min,XING Da~* (MOE Key Laboratory of Life Science & Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China) |
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| Abstract: | The pursuit of efficient and highly target-selective transporters is an active topic in cancer targeting therapy. Here,a novel functioned nanoprobe based on integrin avB3 monoclonal antibody labeled carbon nanotubes was developed to targeting and killing cancer cells under laser irradiation.The results revealed that the nanoprobe had a high efficiency in cancer cell targeting and killing in integrin avB3 positive U87MG cells,could be used as a potential photothermal transduction nanoprobe for cancer targeti... |
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| Keywords: | cancer targeting therapy carbon nanotubes photothermal therapy targeting probe |
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