| 靶向吲哚菁绿纳米探针介导的光声治疗 |
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| 引用本文： | 钟俊平,杨思华.靶向吲哚菁绿纳米探针介导的光声治疗[J].激光生物学报,2012,21(5):470-474. |
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| 作者姓名： | 钟俊平 杨思华 |
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| 作者单位： | 华南师范大学激光生命科学研究所暨激光生命科学教育部重点实验室,广东广州510631 |
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| 基金项目： | 科技部国家重点基础研究973计划项目（2011CB910402,2010CB732602）;教育部“长江学者与创新团队计划”创新团队项目（IRT0829）和国家自然科学基金项目（81127004,11104087） |
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| 摘 要： | 光声治疗是一种利用纳米材料的光声效应选择性破坏癌细胞的方法。本研究采用叶酸作为肿瘤靶向分子,以聚乙二醇包裹吲哚菁绿形成纳米粒子(ICG-PL-PEG-FA),利用此纳米粒子在近红外区的光吸收特性,开展光声治疗研究。实验结果表明,这种叶酸标记的纳米探针对高表达叶酸的EMT6细胞具有高靶向选择性和靶向光杀伤性。这种基于包含吲哚菁绿纳米探针的光声治疗将有潜力发展为一种安全,高效的癌症治疗技术。
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| 关 键 词： | 肿瘤靶向治疗 吲哚菁绿 光声治疗 纳米粒子 聚乙二醇 叶酸 |
Photoacoustic Therapy Using Targeting Indocyanine Green-containing Nanoparticles |
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| ZHONG Junping,YANG Sihua.Photoacoustic Therapy Using Targeting Indocyanine Green-containing Nanoparticles[J].ACTA Laser Biology Sinica,2012,21(5):470-474. |
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| Authors: | ZHONG Junping YANG Sihua |
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| Institution: | ( MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631, Guangdong, China) |
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| Abstract: | Photoacoustic therapy is an approach using the photoacoustic effect of nanoparticle for targeting and selective destruction of cancer cells. Here, a novel functioned nanoprobe based on folic acid labeled indocyanine green-containing nanoparticle was developed to target and kill cancer cells under photoacoustic therapy. The results revealed that the nan- oprobe had a high efficiency in cancer cell targeting and killing in folic acid positive EMT6 cells. The ICG-PL-PEG NPs based photoacoustic therapy would be a safe and highly efficient cancer treatment technique. |
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| Keywords: | cancer targeting therapy indocyanine green photoacoustic therapy nanoparticle phospholipid-polyethy-lene glycol folic acid |
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