| k子串离散源结合加权KNN算法预测膜蛋白类型 |
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| 引用本文： | 姜彬,王正华,王勇献,贺细平.k子串离散源结合加权KNN算法预测膜蛋白类型[J].激光生物学报,2009,18(1). |
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| 作者姓名： | 姜彬 王正华 王勇献 贺细平 |
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| 作者单位： | 1. 国防科技大学计算机学院并行与分布处理国家重点实验室,湖南,长沙,410073
2. 国防科技大学计算机学院并行与分布处理国家重点实验室,湖南,长沙,410073;湖南农业大学信息科学技术学院,湖南,长沙,410128 |
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| 摘 要： | 膜蛋白是生物膜功能的主要体现者,是细胞执行各种功能的物质基础,在细胞中发挥着至关重要的作用.分类预测未知类型的膜蛋白对于生物学相关研究具有指导性意义,是膜蛋白结构与功能研究领域的一项重要基础性工作.针对膜蛋白分类预测问题,利用k子串离散源的方法对膜蛋白序列进行特征提取,并融合最小离散增量方法和加权K近邻算法构建一种新型的膜蛋白分类预测模型,在自检验、Jackknife检验和独立测试集检验三种典型的检验方式下,预测准确率分别为99.95%、86.16%和98.36%.实验结果表明,k子串离散源方法能够有效提取膜蛋白序列的特征信息,与现有方法相比,该分类模型具有较高的分类预测成功率.
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| 关 键 词： | 膜蛋白 k子串 离散源 离散增量 K近邻 |
The Prediction of Membrane Protein Types by k-substring Source of Diversity and Weighted-KNN Algorithm |
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| JIANG Bin,WANG Zheng-hua,WANG Yong-xian,HE Xi-ping.The Prediction of Membrane Protein Types by k-substring Source of Diversity and Weighted-KNN Algorithm[J].ACTA Laser Biology Sinica,2009,18(1). |
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| Authors: | JIANG Bin WANG Zheng-hua WANG Yong-xian HE Xi-ping |
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| Institution: | 1.National Laboratory for Parallel and Distributed Processing;Institute of Computer;National University of Defense Technology;Changsha 410073;Hunan;China;2.School of Information Science and Technology;Hunan Agricultural University;Changsha 410128;China |
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| Abstract: | Membrane proteins is the main manifestation of biological membrane's function.It plays a crucial role in cells and makes the material basis for cells to implement various functions.The prediction for the type of membrane protein is a crucial fundamental research in the field of the structure and function of membrane protein and will also provide guidance for the related research in biology.In order to predict the type of membrane protein,this paper uses the method of k-substring source of diversity to extra... |
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| Keywords: | membrane protein k-substring source of diversity increment of diversity K-nearest neighbor |
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