| 阿魏酸对拟痴呆小鼠学习记忆和海马胶质纤维酸性蛋白表达的影响 |
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| 引用本文： | 金蓓蓓,陈勤,陈庆林.阿魏酸对拟痴呆小鼠学习记忆和海马胶质纤维酸性蛋白表达的影响[J].激光生物学报,2011,20(4):484-489. |
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| 作者姓名： | 金蓓蓓 陈勤 陈庆林 |
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| 作者单位： | 安徽大学生命科学学院,安徽省中药研究与开发重点实验室,安徽合肥230039 |
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| 基金项目： | 安徽省教育厅自然科学研究项目(KJ2009A116); 安徽大学211工程3期教学质量工程项目(0008) |
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| 摘 要： | 目的:探讨阿魏酸对阿尔茨海默病(AD)模型小鼠神经行为学和海马胶质纤维酸性蛋白(GFAP)表达的影响,分析阿魏酸对小鼠脑的保护作用。方法:海马CA1区注射微量红藻氨酸(KA)建立痴呆模型,然后对痴呆小鼠用不同剂量的阿魏酸(FA)灌胃治疗。Morris水迷宫实验观察小鼠行为学变化,免疫组织化学方法观察GFAP的表达。结果:与假手术组相比,模型组学习记忆能力明显降低(P<0.01),GFAP阳性细胞表达明显增多(P<0.01);与模型组相比,阿魏酸治疗组学习记忆能力均明显提高(P<0.01),GFAP阳性细胞表达均明显减少(P<0.01)。结论:用不同剂量的阿魏酸治疗拟AD小鼠后,小鼠学习记忆能力得到明显改善,GFAP表达得到明显抑制,起到保护脑的作用。
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| 关 键 词： | 阿魏酸 阿尔茨海默病 红藻氨酸 学习记忆 胶质纤维酸性蛋白 |
Effect of Ferulic Acid on Learning-memory and Expression of GFAP in the Hippocampus Tissues of Alzheimer's Disease-like Model Mice |
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| JIN Beibei,CHEN Qin,CHEN Qinglin.Effect of Ferulic Acid on Learning-memory and Expression of GFAP in the Hippocampus Tissues of Alzheimer's Disease-like Model Mice[J].ACTA Laser Biology Sinica,2011,20(4):484-489. |
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| Authors: | JIN Beibei CHEN Qin CHEN Qinglin |
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| Institution: | JIN Beibei,CHEN Qin~*,CHEN Qinglin (School of Life Science,Anhui University,Anhui Province Key Laboratory of R&D of Chinese Medicine,Hefei 230039,Anhui,China) |
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| Abstract: | Objective:To investigate the effects of ferulic acid on neurological behavior and the expression of glial fibrillary acidic protein(GFAP) of hippocampus tissues in Alzheimer's disease-like model mice,and to analyze the protective effects of ferulic acid on the brain.Methods:kainic acid(KA) was injected into hippocampus CAI region of mice and to establish Alzheimer's disease-like model,then the drug group with different doses of ferulic acid gavage lasted a month.The learning and memory abilities of the mice... |
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| Keywords: | ferulic acid Alzheimer's disease kainic acid learning and memory glial fibrillary acidic protein |
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