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无损光学法测量人胃粘膜/粘膜下层组织的光衰减特性
引用本文:魏华江,邢达,何博华,陈雪梅,巫国勇,鲁建军.无损光学法测量人胃粘膜/粘膜下层组织的光衰减特性[J].激光生物学报,2007,16(2):167-172.
作者姓名:魏华江  邢达  何博华  陈雪梅  巫国勇  鲁建军
作者单位:1. 华南师范大学激光生命科学研究所、暨激光生命科学教育部重点实验室,广东,广州,510631
2. 广东药学院临床医学系外科,广东,广州,510224
3. 中山大学第一附属医院眼科,广东,广州,510080
4. 中山大学第一附属医院外科,广东,广州,510080
基金项目:国家自然科学基金 , 广东省自然科学基金 , 广东省科技厅科技计划
摘    要:研究了人正常胃粘膜及粘膜下层组织对640 nm,690 nm,740 nm,790 nm,840 nm和890 nm波长的钛宝石激光的光衰减特性以及光学穿透深度,实验采用激光斜入射式空间分辨反射光和CCD探测器以及非线性拟合确定组织光学特性。结果表明:人正常胃粘膜及粘膜下层组织对六个波长的激光的有效衰减系数和光学穿透深度都是随着激光波长的变化而变化的。其有效衰减系数的最大值在640 nm,其值为1.12 mm-1,最小值在790 nm,其值为0.901 mm-1,最大差异在790 nm和890 nm之间,其值为19.9%,最小差异在690 nm和740nm之间,其值为2.83%。其光学穿透深度的最大值在790 nm,其值为1.11 mm,最小值在640 nm,其值为0.890 mm,最大差异在640 nm和790 nm之间,其值为24.7%,最小差异在690 nm和740 nm之间,其值为2.97%。

关 键 词:人胃粘膜/粘膜下层组织  光衰减特性  激光  CCD探测器  空间分辨漫反射光
文章编号:1007-7146(2007)02-0167-06
收稿时间:2006-07-12
修稿时间:2006年7月12日

Noninvasive Measurements for Optical Attenuation Characteristics of Human Stomach Mucosa/Submucosa Tissues Using Optical Methods
WEI Hua-jiang,XING Da,HE Bo-hua,CHEN Xue-mei,WU Guo-yong,LU Jian-jun.Noninvasive Measurements for Optical Attenuation Characteristics of Human Stomach Mucosa/Submucosa Tissues Using Optical Methods[J].ACTA Laser Biology Sinica,2007,16(2):167-172.
Authors:WEI Hua-jiang  XING Da  HE Bo-hua  CHEN Xue-mei  WU Guo-yong  LU Jian-jun
Institution:1. MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal university, Guangzhou 510631, Guangdong, China; 2. Department of Surgery, Guangd0ng College of Pharmacy, Guangzhou 510224, Guangdong, China; 3. Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China; 4. Department of Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China
Abstract:The purpose of the study is to determine the optical attenuation characteristics and the optical penetration depths for normal human stomach mucosa/submucosa tissues in vitro at 640,690,740,790,840 and 890 nm wavelength of laser.The measurements were performed using a CCD detector,and the optical properties were assessed from the measurements using an obliquely incident laser beam,and spatially resolved reflectance,and nonlinear fitting of diffusion equation.The results of measurements showed that the optical attenuation characteristics and the optical penetration depths for the tissue samples at six different laser wavelengths vary with a change of laser wavelength.The maximum optical attenuation characteristic for tissue samples is 1.12 mm-1 at 640 nm,and the minimum optical attenuation characteristic is 0.901 mm-1 at 790 nm,and the maximum difference in the optical attenuation characteristics is 19.9 % between 790 nm and 890 nm,and the minimum difference is 2.83 % between 690 nm and 740 nm.The maximum optical penetration depth for tissue samples is 1.11 mm at 790 nm,and the minimum optical penetration depth is 0.890 mm at 640 nm,and the maximum difference in the optical penetration depths is 24.7 % between 640 nm and 790 nm,and the minimum difference is 2.97 % between 690 nm and 740 nm.
Keywords:human stomach mucosa/submucosa tissue  optical attenuation characteristics  laser  CCD detector  spatially resolved reflectance
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