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| 微小RNA与肿瘤干细胞耐药的研究进展 | |
| 引用本文： | 陈夏,陶怀,何迎春,宋岚,程莉娟,周芳亮.微小RNA与肿瘤干细胞耐药的研究进展[J].激光生物学报,2014,23(5):385-389. |
| 作者姓名： | 陈夏 陶怀 何迎春 宋岚 程莉娟 周芳亮 |
| 作者单位： | 1. 中南大学湘雅二医院骨科,湖南长沙,410011 2. 湖南中医药大学生物化学与分子生物学教研室,湖南长沙410208;湖南中医药大学干细胞调控与应用实验室,湖南长沙410208 3. 湖南中医药大学生物化学与分子生物学教研室,湖南长沙,410208 |
| 基金项目： | 干细胞中药调控与应用实验室开放基金项目，湖南中医药大学博士启动基金干细胞中药调控与应用实验室开放基金项目，国家自然科学基金项目 |
| 摘 要： | 肿瘤干细胞（Cancer stem cells,CSCs）是肿瘤组织中一小部分具有自我更新和致瘤性的细胞,具有特殊的耐药机制,与肿瘤的复发和治疗失败关系密切。微小RNA（microRNAs,miRNAs）是一类长度约为19～25个核苷酸的内源性非编码单链RNA,能够通过调控相关靶基因的表达,参与调控肿瘤干细胞增殖、凋亡、上皮-间质转化等重要的生命过程,引起CSCs对化疗药物产生原发性多药耐药性。本论文就miRNAs在调控CSCs多药耐药性方面的研究进展作一综述。 |
| 关 键 词： | 肿瘤干细胞 microRNA 耐药 |
Advanced Research on the Drug Resistance of Cancer Stem Cells and MicroRNA |
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| CHEN Xia,TAO Huai,HE Yingchun,SONG Lan,CHEN Lijuan,ZHOU Fangliang.Advanced Research on the Drug Resistance of Cancer Stem Cells and MicroRNA[J].ACTA Laser Biology Sinica,2014,23(5):385-389. | |
| Authors: | CHEN Xia TAO Huai HE Yingchun SONG Lan CHEN Lijuan ZHOU Fangliang |
| Institution: | CHEN Xia, TAO Huai. , HE Yingchun , SONG Lart , CHEN Lijuan , ZHOU Fangliang (1. Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; 2. Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; 3. Division of Stem Cell Regulation and Application, Hunan University of Chinese Medieine, Changsha 410208, Hunan, China) |
| Abstract: | Cancer stem cells （CSCs） are a subpopulation of tumor cells that possess self-renewal to regenerate them- selves and tumor initiation capacity. CSCs possess special intrinsic Inechanisins of resistance to chemotherapeutic drugs, leading to cancer recurrence and treatment failure. MicroRNAs （ IniRNAs ） are short endogenous non-coding single- stranded RNAs that consist of 21 to 25 nucleotides. They play important roles in several cellular processes of CSCs by regulating the expression of related target genes, such as proliferation, apoptosis, and epithelial-mesenchymal transition （EMT） , leading to primary CSCs drug resistance. The progress of IniRNAs regulation in CSCs drug resistance was re- viewed. |
| Keywords: | cancer stem cells microRNA drug resistance |
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