AFM探测缺铁性贫血病人的红细胞

在纳米量级上探测红细胞生理病理特性对于揭示疾病的起源、早期诊断和有效的治疗是十分重要的。疾病可以从分子水平上扰乱红细胞的形貌和功能。缺铁性贫血病人的红细胞的形貌具有严重的表面畸形。通过高分辨率的原子力显微镜成像研究了健康人和缺铁性贫血病人红细胞的整个形貌和表面膜的差异。结果表明,红细胞的形貌参数（例如细胞的峰、谷、峰谷差、表面起伏和标准方差）可以探测健康和病理的红细胞。因此,红细胞的形貌信息可望成为诊断健康和疾病,以及评估治疗效果的重要指标。

A Study of Red Blood Cells in Patients with Iron-deficiency Anemia Using Atomic Force Microscopy

The pathological changes of red blood cells(RBCs) were detected at the nanometer scale,which was important for revealing the onset of diseases,early diagnosis,and effective therapies.Diseases may disturb the morphology and function of RBCs at molecular scale.There were dramatic surface deformations in topography of RBCs from patients with iron-deficiency anemia.The difference of the overall shape and surface membrane in RBCs from healthy people and iron-deficiency anemia patients have been studied by high-resolution atomic force microscopy imaging.The results showed that healthy and pathological RBCs can be detected by the morphologic parameters of the peak,valley,valley-to-peak,surface fluctuation,and standard deviations of the RBCs.Therefore,the morphologic information of RBCs is a very important indictor for diagnosing the healthy and disease,as well as evaluating therapeutic effects.