|
|||||
|
|
Sanguinarine-induced G1-phase arrest of the cell cycle results from increased p27KIP1 expression mediated via activation of the Ras/ERK signaling pathway in vascular smooth muscle cells |
|
| Authors: | Lee Beobyi Lee Se-Jung Park Sung-Soo Kim Si-Kwan Kim Sung-Ryong Jung Jae-Hyun Kim Wun-Jae Moon Sung-Kwon |
| Institution: | a Department of Anatomy, College of Medicine, Konkuk University, Chungju City, Chungbuk 380-701, South Korea b Cheju Traditional Food Institute, Cheju Halla College, Nohyung-dong 1534, Jeju-si, Jeju-do, South Korea c Department of Life Science, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, South Korea d Department of Polymer Science and Engineering, College of Science and Technology, Chungju National University, Chungju, Chungbuk 380-702, South Korea e Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk 361-763, South Korea f Department of Food and Biotechnology, Chungju National University, 123 Geomdan-ri Iryu-myeon, Chungju, Chungbuk 380-702, South Korea |
| Abstract: | The present study identified a novel mechanism for the effects of sanguinarine in vascular smooth muscle cells (VSMC). Sanguinarine treatment of VSMC resulted in significant growth inhibition as a result of G1-phase cell-cycle arrest mediated by induction of p27KIP1 expression, and resulted in a down-regulation of the expression of cyclins and CDKs in VSMC. Moreover, sanguinarine-induced inhibition of cell growth appeared to be linked to activation of Ras/ERK through p27KIP1-mediated G1-phase cell-cycle arrest. Overall, the unexpected effects of sanguinarine treatment in VSMC provide a theoretical basis for clinical use of therapeutic agents in the treatment of atherosclerosis. |
| Keywords: | Sanguinarine VSMC ERK G1-phase cell-cycle arrest p27 Ras |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |