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The Biological Properties of Cyclopenin and Cyclopenol |
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| Authors: | Cutler Horace G; Crumley Farrist G; Cox Richard H; Wells John M; Cole Richard J |
| Institution: | 1U.S. Department of Agriculture, Agricultural Research Service, Plant Physiology Unit, Richard B. Russell Agricultural Research Center Athens, Georgia 30613, U.S.A. 2Philip Morris USA, Research center Richmond, Virginia 23261, U.S.A. 3U.S. Department of Agriculture, Agricultural Research Service, Cook College, Rutgers University New Brunswick, New Jersey 08903, U.S.A. 4U.S. Department of Agriculture, Agricultural Research Service, National Peanut Research Laboratory Dawson, Georgia 31742, U.S.A. |
| Abstract: | Cyclopenin (C17H14O3N2) and cyclopenol (C17H14O4N2), isolatedfrom an abberent strain of Penicillium cyclopium (NRRL 6233),significantly inhibited the growth of etiolated wheat (Triticumaestivum) coleoptile segments. The former inhibited at 10–3and 10–4 M, the latter at 10–3 M. Cyclopenin producedmalformation of the first set of trifoliate leaves in bean (Phaseolusvulgaris) at 10–2 M and necrosis and stunting in corn(Zea mays) at 10–2 M. Cyclopenol induced no apparent effectsin bean or corn plants. Neither compound changed the growthor morphology of tobacco (Nicotiana tabacum) plants. Cyclopenininduced intoxication, prostration and ataxia in day-old chicksat 500 mg/kg, but they recovered within 18 hours. Cyclopenolwas inactive against chicks when dosed at levels up to 500 mg/kg. (Received October 11, 1983; Accepted December 15, 1983) |
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