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Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin |
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| Authors: | Kazuyuki Tanabe Thibaut Jombart Shun Horibe Nirianne MQ Palacpac Hajime Honma Shin-Ichiro Tachibana Masatoshi Nakamura Toshihiro Horii Hirohisa Kishino Toshihiro Mita |
| Institution: | 1. Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan;2. Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan;3. MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College, London W2 1PG, UK;4. Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan;5. Department of International Affairs and Tropical Medicine, Tokyo Women''s Medical University, Tokyo, Japan;6. Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan;7. Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi 321-0293, Japan;8. Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan |
| Abstract: | The geographical distribution of single nucleotide polymorphism (SNP) in the mitochondrial genome of the human malaria parasite Plasmodium falciparum was investigated. We identified 88 SNPs in 516 isolates from seven parasite populations in Africa, Southeast Asia and Oceania. Analysis of the SNPs postulated a sub-Saharan African origin and recovered a strong negative correlation between within-population SNP diversity and geographic distance from the putative African origin over Southeast Asia and Oceania. These results are consistent with those previously obtained for nuclear genome-encoded housekeeping genes, indicating that the pattern of inheritance does not substantially affect the geographical distribution of SNPs. |
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