Time-course of lipid peroxidation in different organs of mice treated with Echis pyramidum snake venom |
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Authors: | Al Asmari Abdurrahman Al Moutaery Khalaf Manthari Rajamohamed Abbas Khan Haseeb Ahmad |
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Institution: | Research Center, Armed Forces Hospital, P.O. Box 7897 (775S), Riyadh 11159, Saudi Arabia. rkh_research@yahoo.com |
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Abstract: | This study examined the effect of Echis pyramidum (EP) venom on time-course of lipid peroxidation in different vital organs of mice. Adult male Swiss albino mice were injected with EP venom (2 mg/kg, i.p.); control mice received vehicle alone (normal saline). Mice were killed at 1, 3, 6, 12, and 24 h post-envenomation. The liver, lung, kidney, heart, and brain (cerebrum and cerebellum) were collected for the estimation of malondialdehyde (MDA), an index of lipid peroxidation. The results of this study showed that a single injection of EP venom caused a significant lipid peroxidation in all the organs studied. The onset of lipid peroxidation was as early as 1 h and persisted for several hours, suggesting an important role of oxidative stress in the cytotoxicity of EP venom. |
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Keywords: | Snake venom Echis pyramidum Lipid peroxidation Malondialdehyde Mice |
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