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Focus: A Multifaceted Battle Against Cancer: Basal Cell Carcinoma: Pathogenesis,Epidemiology, Clinical Features,Diagnosis, Histopathology,and Management
Authors:Alexander G Marzuka  Samuel E Book
Institution:aDepartment of Dermatology, Yale School of Medicine, New Haven, Connecticut;bDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
Abstract:Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease. The pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management of BCC will be discussed in this review.
Keywords:basal cell carcinoma  BCC  electrodesiccation and curettage  ED&  C  surgical excision  Mohs surgery
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