首页 | 本学科首页   官方微博 | 高级检索  
   检索      

纳米基因转运体——原理、研制与应用
引用本文:朱诗国,李桂源.纳米基因转运体——原理、研制与应用[J].生物化学与生物物理进展,2002,29(6):868-871.
作者姓名:朱诗国  李桂源
作者单位:中南大学湘雅医学院肿瘤研究所,长沙,410078
基金项目:国家自然科学基金资助项目(30171056),教育部科学技术研究重点项目(01130),教育部重大项目基金(2000-156),湖南省自然科学基金项目(01JJY2020).
摘    要:基因转移是基因治疗的关键技术,一直以来也是制约基因治疗成功开展的瓶颈问题.随着纳米技术的发展,纳米基因转运体的研制获得了积极发展,其系统内和细胞内基因转移机理得到了深入阐明.设计与研制在体内循环时间长、具有靶特异性的纳米转运体为突破基因转移瓶颈,实现安全、高效和靶向性基因治疗带来了新的希望.

关 键 词:纳米颗粒,纳米转运体,基因传递,基因治疗
收稿时间:2002/5/13 0:00:00
修稿时间:2002年5月13日

Nanoparticulate Carriers for Gene Delivery: Principles, Research and Applications
ZHU Shi-Guo and LI Gui-Yuan.Nanoparticulate Carriers for Gene Delivery: Principles, Research and Applications[J].Progress In Biochemistry and Biophysics,2002,29(6):868-871.
Authors:ZHU Shi-Guo and LI Gui-Yuan
Institution:Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China
Abstract:Although genomic research has opened up more new avenues for therapeutic interventions based on genetic therapy, it will not be possible to realize the full potential of these therapies until the issue of gene delivery has been resolved. With the development of nanotechnology, the systemic and cellular mechanisms of nanoparticulate carriers for gene delivery have been gradually elucidated. Research and applications of long-circulating and target-specific nanoparticulate carriers maybe help to allevate the gene delivery bottleneck, and realize the efficient, targeted and safe gene delivery.
Keywords:nanoparticles  nanoparticulate carriers  gene delivery  gene therapy
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《生物化学与生物物理进展》浏览原始摘要信息
点击此处可从《生物化学与生物物理进展》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号