| 生长激素释放肽的合成及促生长活性 |
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| 引用本文： | 胡晓愚,王勤,王锐,高立伟,沈剑敏,王永谦.生长激素释放肽的合成及促生长活性[J].生物化学与生物物理进展,1995,22(6):549-552. |
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| 作者姓名： | 胡晓愚 王勤 王锐 高立伟 沈剑敏 王永谦 |
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| 作者单位： | 兰州大学生物系;甘肃兰州大学生物系生化教研室;兰州大学生物系;兰州大学生物系;兰州大学生物系;兰州大学生物系 |
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| 基金项目： | 甘肃省科委科学技术攻关项目. |
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| 摘 要： | 用固相多肽合成法合成了生长激素释放肽(GHRP),这是一种含D-型氨基酸的外源性激素,具有促进脑下垂体分泌生长激素功能的人工合成六肽,其氨基酸序列为His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.观察了使用不同剂量的GHRP对不同日龄小鼠的促生长效应,当使用最佳剂量(1000μg/kg)时,可使25日龄小鼠体重较对照组增加14.8%,同时发现鼠龄越小对GHRP越敏感,当使用剂量高达10mg/kg时仍然安全无毒.
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| 关 键 词： | 生长激素释放肽（GHRP） 多肽固相法合成 小白鼠 促生长作用 |
| 收稿时间： | 1994/12/12 0:00:00 |
| 修稿时间： | 1995/3/28 0:00:00 |
The Synthesis of Growth Hormone Releasing Peptide (GHRP) and Its Activity of Enhanced Growth on Mice |
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| Hu Xiaoyu,Wang Qin,Wang Rui,Gao Liwei,Shen Jianmin and Wang Yongqian.The Synthesis of Growth Hormone Releasing Peptide (GHRP) and Its Activity of Enhanced Growth on Mice[J].Progress In Biochemistry and Biophysics,1995,22(6):549-552. |
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| Authors: | Hu Xiaoyu Wang Qin Wang Rui Gao Liwei Shen Jianmin and Wang Yongqian |
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| Institution: | Department of Biology; Lanzhou University;Department of Biology; Lanzhou University;Department of Biology; Lanzhou University;Department of Biology; Lanzhou University;Department of Biology; Lanzhou University;Department of Biology; Lanzhou University |
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| Abstract: | Growth hormone releasing peptide (GHRP) was synthesized.It is an exogenous hormone promoting pituitary to release growth hormone.The amino acid sequence of GHRP is His-D-Trp-Ala-D-Phe-Lys-NH2.The synthesis was carried out with SPPS and Boc strategy.The amino acid composition was found in agreement with its caculated values. The purity was 97.7%.The bioassays showed that it enhanced the growth of young mice significantly and this effect depends on the dosage of injection. GHRP is more sensitive to the younger mice. |
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| Keywords: | growth hormone releasing peptide(GHRP) solid phase sythesis mice growthenhancement |
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