| 肿瘤能量代谢机制研究进展 |
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| 引用本文： | 罗湘建,曹亚.肿瘤能量代谢机制研究进展[J].生物化学与生物物理进展,2011,38(7):585-592. |
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| 作者姓名： | 罗湘建 曹亚 |
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| 作者单位： | 中南大学肿瘤研究所，长沙 410078；中南大学分子影像研究中心，长沙 410078;中南大学肿瘤研究所，长沙 410078；中南大学分子影像研究中心，长沙 410078 |
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| 基金项目： | 国家自然科学基金资助项目(90813028, 30801387, 30930101) |
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| 摘 要： | 细胞的能量主要来自糖酵解和线粒体的有氧氧化.细胞活性和能量状态密切相关,恶性肿瘤由于其生长迅速,常常出现葡萄糖摄取量增高、糖酵解增加和乳酸堆积现象.通过介绍肿瘤能量代谢机制研究进展,结合代谢成像技术,将会有助于深入揭示肿瘤能量代谢改变与肿瘤进展的因果关联,为靶向能量代谢的肿瘤治疗策略提供新的视野和契机.
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| 关 键 词： | 能量代谢 Warburg效应 低氧诱导因子 p53 |
| 收稿时间： | 2010/11/26 0:00:00 |
| 修稿时间： | 2011/2/23 0:00:00 |
Research progress on bioenergy metabolic mechanism of cancer |
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| LUO Xiang-Jian and CAO Ya.Research progress on bioenergy metabolic mechanism of cancer[J].Progress In Biochemistry and Biophysics,2011,38(7):585-592. |
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| Authors: | LUO Xiang-Jian and CAO Ya |
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| Institution: | LUO Xiang-Jian1,2),CAO Ya1,2)(1) Cancer Research Institute of Central South University,Changsha 410078,China,2) The Molecular Imaging Center of Central South University,China) |
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| Abstract: | The cellular energy derives mainly from glycolysis and mitochondrial oxidation, and cellular activity correlates closely with energy status. Cancer cells have much higher rate of glucose uptake and increased glycolysis, produce high levels of lactate. Current advances in bioenergy metabolic mechanism of cancer were expounded. With intense investigation in this field combined development of metabolic imaging techniques, it will benefit unveiling the causal relationship between metabolic alteration and progress of cancer and be harnessed therapeutically. |
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| Keywords: | energy metabolism warburg effect hypoxia-induced factor p53 |
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