| 铁代谢蛋白在肾脏的表达与功能 |
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| 引用本文： | 蔺 艳,钱忠明,柯 亚.铁代谢蛋白在肾脏的表达与功能[J].生物化学与生物物理进展,2011,38(2):113-118. |
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| 作者姓名： | 蔺 艳 钱忠明 柯 亚 |
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| 作者单位： | 香港理工大学应用生物化学系，香港；香港中文大学医学院生物医学学院，香港;香港理工大学应用生物化学系，香港;香港中文大学医学院生物医学学院，香港 |
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| 摘 要： | 最近的研究证实,肾小管细胞具有能力表达包括转铁蛋白受体1(transferrin receptor-1,TfR1)、二价金属离子转运蛋白1(divalent metal transporter-1,DMT1)、膜铁转运蛋白1(ferroportin-1,FPN1)、铁调节蛋白(iron regulatory protein,IRP)和铁调素(hepcidin,Hepc)在内的几乎所有铁代谢蛋白.这些蛋白质的存在以及相关研究显示肾脏可能具有排出多余铁的功能,因此对体铁平衡起有十分重要的作用.
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| 关 键 词： | 肾小管 铁代谢蛋白 排铁 铁平衡 |
| 收稿时间： | 2010/5/26 0:00:00 |
| 修稿时间： | 2010/7/28 0:00:00 |
Expression and Function of Iron Metabolism Proteins in The Kidney |
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| LIN Yan,QIAN Zhong-Ming and KE Ya.Expression and Function of Iron Metabolism Proteins in The Kidney[J].Progress In Biochemistry and Biophysics,2011,38(2):113-118. |
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| Authors: | LIN Yan QIAN Zhong-Ming and KE Ya |
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| Institution: | Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China;School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China;Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China;School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China |
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| Abstract: | Recent studies demonstrated that the kidney has the ability to express transferrin receptor-1 (Tf R1), divalent metal transporter-1 (DMT1), ferroportin-1 (FPN1), iron regulatory protein (IRP), hepcidin (Hepc) and other iron metabolism proteins. The existence of these proteins and the relevant studies about their functions suggested that the kidney might be an efficient way of eliminating excess iron, and therefore play an important role in human iron homeostasis. |
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| Keywords: | nephron iron metabolism proteins elimination of excess iron iron homeostasis |
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