| 利用cDNA-RDA技术研究BXSB狼疮小鼠差异表达的基因 |
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| 引用本文： | 韩文玲,李莹,杨高云,宋泉声,张颖妹,狄春辉,马大龙.利用cDNA-RDA技术研究BXSB狼疮小鼠差异表达的基因[J].生物化学与生物物理进展,2000,27(3):305-308. |
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| 作者姓名： | 韩文玲 李莹 杨高云 宋泉声 张颖妹 狄春辉 马大龙 |
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| 作者单位： | 北京医科大学卫生部免疫学重点实验室,北京,100083 |
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| 摘 要： | 利用近年来发展起来的代表性差异分析cDNA-RDA(cDNA-representational difference analysis)技术筛选BXSB红斑狼疮小鼠发病相关基因.发现了3个新的表达序列标签(EST)片段，在GenBank中的登录号分别为AF060113, AF060111, AF060110，同时发现了一些已知与自身免疫病相关的基因如逆转录病毒衣壳蛋白、Line-1逆转录酶等.通过RDA技术可能发现系统性红斑狼疮发病相关新基因，为自身免疫病的理论研究提供新的思路和方法.
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| 关 键 词： | 系统性红斑狼疮，代表性差异分析，BXSB小鼠 |
| 收稿时间： | 1999/6/28 0:00:00 |
| 修稿时间： | : |
Isolation of the Differentially Expressed Genes in the BXSB Mouse Model of Systemic Lupus Erythematosus by cDNA-RDA Technique |
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| HAN Wen-Ling,LI Ying,YANG Gao-Yun,SONG Quan-Sheng,ZHANG Ying-Mei,DI Chun-Hui and MA Da-Long.Isolation of the Differentially Expressed Genes in the BXSB Mouse Model of Systemic Lupus Erythematosus by cDNA-RDA Technique[J].Progress In Biochemistry and Biophysics,2000,27(3):305-308. |
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| Authors: | HAN Wen-Ling LI Ying YANG Gao-Yun SONG Quan-Sheng ZHANG Ying-Mei DI Chun-Hui and MA Da-Long |
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| Institution: | Department of Immunology, Beijing Medical University, Beijing 100083, China;Department of Immunology, Beijing Medical University, Beijing 100083, China;Department of Immunology, Beijing Medical University, Beijing 100083, China;Department of Immunology, Beijing Medical University, Beijing 100083, China;Department of Immunology, Beijing Medical University, Beijing 100083, China;Department of Immunology, Beijing Medical University, Beijing 100083, China;Department of Immunology, Beijing Medical University, Beijing 100083, China |
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| Abstract: | |
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| Keywords: | systemic lupus erythematosus representational difference analysis BXSB mice |
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