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综述与专论: 免疫突触形成的生物学特点及其光学成像研究
引用本文:林玮,储以微.综述与专论: 免疫突触形成的生物学特点及其光学成像研究[J].生物化学与生物物理进展,2017,44(12):1066-1073.
作者姓名:林玮  储以微
作者单位:山东省医学科学院基础医学研究所微生物室,济南 250062;山东中医药大学眼科研究所,济南 250002,复旦大学基础医学院免疫学系,上海 200032
基金项目:国家自然科学基金青年项目(81500710),山东省卫生厅科技发展计划(2015WS0194),山东省医学科学院科学发展计划(2015-25)和山东省医学科学院创新基金资助项目
摘    要:免疫突触(immunological synapse,IS)是抗原提呈细胞与T细胞免疫识别时,多种分子参与、分阶段不断变化的过程,涉及黏附分子、细胞因子、信号传导分子、细胞骨架蛋白等多分子的聚集或离散.其形成不仅促进T细胞和抗原提呈细胞的稳定接触,而且激活T细胞信号传导途径,促进T细胞的活化和增殖.对IS的研究可以从分子水平解释免疫激活、免疫耐受、病原微生物感染与免疫细胞相互作用的机制,为进一步揭示疾病发生的分子机制,寻求疾病防治的靶向分子提供新的思路.近年来,光学成像的发展为可视化研究IS形成与T细胞活化的关系提供了有力帮助,为研究生理病理状态下的免疫应答提供了有力工具.

关 键 词:免疫突触(IS),T细胞,抗原提呈细胞,免疫应答,光学成像
收稿时间:2017/11/14 0:00:00
修稿时间:2017/12/1 0:00:00

Reviews and Monographs: Biological Characteristics and Optical Imaging Research of Immunological Synapse Formation
LIN Wei and CHU Yi-Wei.Reviews and Monographs: Biological Characteristics and Optical Imaging Research of Immunological Synapse Formation[J].Progress In Biochemistry and Biophysics,2017,44(12):1066-1073.
Authors:LIN Wei and CHU Yi-Wei
Institution:Department of Microbiology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China; Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, China and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Abstract:Immunological synapse (IS) is a specialized and sophisticated supramolecular activation cluster structure that is formed at the interface between T cell and antigen presenting cells. It is a dynamic multistage progress, involving adhesion molecules, cytokines, signaling molecules, cell cytoskeletal proteins and other molecules. IS is not only contribute to the stability of the contact between T cells and APC, but also promotes T-cell activation and proliferation through T cells signaling pathway. Studying of the immunological synapse could explain molecular mechanisms of immune activation, immune tolerance, and the mechanism of interaction between pathogenic microbes and immune cells, which will provide new ideas for further revealing the pathogenic mechanism of disease, and seeking new target molecules for disease control and prevention. Recently, optical imaging provides a powerful help for visualization on the relationship between IS formation and T-cell activation. It provides a powerful tool for studying the immune response under physiological and pathological conditions.
Keywords:immunological synapse  T cell  antigen processing cell  immune response  optical imaging
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