| 体细胞重编程逆转为干细胞的研究进展 |
| |
| 引用本文： | 邱小燕,李跃民. 体细胞重编程逆转为干细胞的研究进展[J]. 生物化学与生物物理进展, 2008, 35(4): 368-372 |
| |
| 作者姓名： | 邱小燕 李跃民 |
| |
| 作者单位： | 1. 西南大学动物科技学院,重庆,400715
2. 西南大学胚胎工程实验室,重庆,400715 |
| |
| 摘 要： | 目前细胞和发育生物学上的研究成果为生物医学研究提供了广泛的前景.将完全分化的细胞重编程,不经过胚胎逆转为多能干细胞状态,这点燃了再生医学应用的新希望,这一成果从法律、道德、伦理等不同方面被人们所接受.通过体细胞克隆胚胎获得干细胞所面临的破坏胚胎的伦理限制,促使研究者去寻求将分化细胞重编程逆转为干细胞的新方法.主要论述了体细胞重编程的原理、过程及不经过胚胎逆转为多能干细胞的方法.
|
| 关 键 词： | 体细胞 重编程 干细胞 多能干细胞 编程 研究进展 Stem Cells Somatic Cells 过程 原理 方法 破坏 克隆胚胎 伦理 道德 法律 新希望 医学应用 再生 状态 完全 前景 生物医学研究 |
| 收稿时间： | 2007-08-17 |
| 修稿时间： | 2007-08-17 |
Progress in Reprogramming Somatic Cells Into Stem Cells |
| |
| qiuxiaoyan and LI Yue-Min. Progress in Reprogramming Somatic Cells Into Stem Cells[J]. Progress In Biochemistry and Biophysics, 2008, 35(4): 368-372 |
| |
| Authors: | qiuxiaoyan and LI Yue-Min |
| |
| Affiliation: | College of Animal Science and Technology, Southwest University, Chongqing 400715, China;Embryo engineering Laboratory, Southwest University, Chongqing 400715, China |
| |
| Abstract: | Recent scientific achievements in cell and developmental biology have provided unprecedented opportunities for advances in biomedical research. The demonstration that fully differentiated cells can reverse their gene expression profile to that of pluripotent cells, and the successful derivation and culture of human embryonic stem cells (ESCs) have fuelled hopes for applications in regenerative medicine. Ethical issues concerning the use of cloned human embryos for the derivation of stem cells have stimulated the search for alternative methods for reversing differentiated cells into pluripotent cells. The present state of these reprogramming technologies will be reviewed and their relative success will be discussed. |
| |
| Keywords: | differentiated cells(somatic cells) reprogramming pluripotent cells(stem cells) |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
|
点击此处可从《生物化学与生物物理进展》下载全文 |
