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| LIM蛋白KyoT在小鼠胚胎发育中的表达 | |
| 引用本文： | 李荣,程轶梦,陈蕾,胡静,孙强,黄红艳,王键,韩骅.LIM蛋白KyoT在小鼠胚胎发育中的表达[J].生物化学与生物物理进展,2003,30(1):95-98. |
| 作者姓名： | 李荣 程轶梦 陈蕾 胡静 孙强 黄红艳 王键 韩骅 |
| 作者单位： | 1. 第四军医大学医学遗传学与发育生物学教研室,西安,710032 2. 西北农林科技大学生命科学院生物化学与分子生物学教研室,杨凌,712100 3. 第四军医大学组织学与胚胎学教研室,西安,710032 |
| 摘 要： | LIM结构域蛋白KyoT可与转录因子RBP-J相互作用而修饰Notch信号途径.以往发现KyoT在成年小鼠肺脏、肾脏和睾丸中有特异性表达，为进一步明确KyoT在小鼠胚胎阶段的表达，故分析了KyoT在小鼠不同胚胎阶段的表达水平变化和胚胎17天时各组织的表达分布.采用RNA印迹发现KyoT在小鼠胚胎的各阶段均表达，而且胚胎17天时表达水平最高.进一步RNA印迹和免疫组织化学检测发现，KyoT mRNA和蛋白质在胚胎17天小鼠的肺、肾以及肌肉中均有高水平的表达.上述结果提示，KyoT在小鼠胚胎发育过程中有特异性表达，且在胚胎17天时KyoT表达器官分布与成年小鼠相似，特异性定位于肺、肾和肌肉等脏器. |
| 关 键 词： | LIM结构域，KyoT，小鼠，胚胎发育 |
| 收稿时间： | 2002/6/13 0:00:00 |
| 修稿时间： | 8/2/2002 12:00:00 AM |
Expression of LIM Protein KyoT in Mice Embryogenesis |
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| LI Rong,CHENG Yi-Meng,CHEN Lei,HU Jing,SUN Qiang,HUANG Hong-Yan,WANG Jian and HAN Hua.Expression of LIM Protein KyoT in Mice Embryogenesis[J].Progress In Biochemistry and Biophysics,2003,30(1):95-98. | |
| Authors: | LI Rong CHENG Yi-Meng CHEN Lei HU Jing SUN Qiang HUANG Hong-Yan WANG Jian and HAN Hua |
| Institution: | Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China;Department of Biochemistry and Molecular Biology, Life Science Institute, Northwest Science and Technology University of Agriculture and Forestry, Yangling 712100, China;Department of Histology and Embryology, The Fourth Military Medical University, Xi'an 710032, China;Department of Histology and Embryology, The Fourth Military Medical University, Xi'an 710032, China;Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China;Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China;Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China;Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China |
| Abstract: | |
| Keywords: | LIM domain KyoT mouse embryogenesis |
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