| 核膜血影重复蛋白研究进展 |
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| 引用本文： | 赵春霞,崔映宇,陈义汉.核膜血影重复蛋白研究进展[J].生物化学与生物物理进展,2014,41(4):337-344. |
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| 作者姓名： | 赵春霞 崔映宇 陈义汉 |
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| 作者单位： | 心律失常教育部重点实验室(同济大学)，上海 200092；同济大学医学遗传研究所，上海 200092,心律失常教育部重点实验室(同济大学)，上海 200092；同济大学医学遗传研究所，上海 200092；同济大学医学院再生医学系，上海 200092,心律失常教育部重点实验室(同济大学)，上海 200092；同济大学医学遗传研究所，上海 200092；同济大学医学院病理与生理学系，上海 200092；同济大学附属东方医院心脏内科，上海 200120 |
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| 基金项目： | 国家重点基础研究发展计划(973)(2013CB531100), 国家自然科学基金委员会创新研究群体项目(81221001), 国家自然科学基金委员会重大国际(地区)合作项目(81120108004), 同济大学医学院扬帆计划项目(2012YF05)资助 |
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| 摘 要： | 核膜血影重复蛋白(Nesprins)连接细胞核与多种细胞骨架和(/或)细胞器,在细胞核与细胞骨架定位、质-核间物质运输和动力传导、核膜构建、细胞迁移、锚定和极性建立等过程中发挥重要作用.本文综述核膜血影重复蛋白的发现、编码基因、结构、功能以及与相关疾病的关系研究现状,并展望潜在的未来研究动向.
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| 关 键 词： | 核膜血影重复蛋白 细胞骨架 细胞核 核纤层蛋白病 |
| 收稿时间： | 2013/4/26 0:00:00 |
| 修稿时间： | 2013/9/22 0:00:00 |
Progress of The Research on Nesprins |
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| ZHAO Chun-Xi,CUI Ying-Yu and CHEN Yi-Han.Progress of The Research on Nesprins[J].Progress In Biochemistry and Biophysics,2014,41(4):337-344. |
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| Authors: | ZHAO Chun-Xi CUI Ying-Yu and CHEN Yi-Han |
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| Institution: | Key Laboratory of Arrhythmias, Ministry of Education (Tongji University), Shanghai 200092, China;Institute of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China,Key Laboratory of Arrhythmias, Ministry of Education (Tongji University), Shanghai 200092, China;Institute of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China;Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, China and Key Laboratory of Arrhythmias, Ministry of Education (Tongji University), Shanghai 200092, China;Institute of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China; Department of Pathophysiology, Tongji University School of Medicine, Shanghai 200092,China;Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China |
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| Abstract: | The nuclear envelope spectrin repeat proteins (Nesprins), connecting the nucleus with many kinds of cytoskeleton and/or organelles, play important roles in nucleus and cytoskeleton positioning, power and material transporting between nucleus and cytoplasm, nuclear envelope constructing, cell migrating, anchoring and polarizing. Their discoveries, encoding genes, structural characters, functions and related diseases were summarized in this review, and their further research pulses are also prospected meanwhile. |
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