| 真核生物中的“双重编码”现象 |
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| 引用本文： | 申志勇,李稚锋,杭兴宜,张成岗.真核生物中的“双重编码”现象[J].生物化学与生物物理进展,2009,36(5):536-540. |
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| 作者姓名： | 申志勇 李稚锋 杭兴宜 张成岗 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,蛋白质组学国家重点实验室,北京,100850 |
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| 基金项目： | 国家重点基础研究发展规划项目(973)(2006CB504100, 2003CB715900)，国家自然科学基金资助项目(30771230, 30772293)和北京市自然科学基金重点项目(7061004). |
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| 摘 要： | 双重编码(dual coding)是指一段mRNA序列同方向上存在两个开放阅读框架，从而可编码不同氨基酸序列的现象．双重编码现象在原核生物、噬菌体和病毒中作为一种可有效利用基因组的方式而普遍存在．新近报道，在真核生物中也存在双重编码现象，对于认识真核生物基因表达调控的机制提供了新的信息．
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| 关 键 词： | 双重编码基因 开放阅读框架 真核生物 |
| 收稿时间： | 9/6/2008 12:00:00 AM |
| 修稿时间： | 2008/10/27 0:00:00 |
Dual Coding Genes in Eukaryote |
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| SHEN Zhi-Yong,LI Zhi-Feng,HANG Xing-Yi and ZHANG Cheng-Gang.Dual Coding Genes in Eukaryote[J].Progress In Biochemistry and Biophysics,2009,36(5):536-540. |
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| Authors: | SHEN Zhi-Yong LI Zhi-Feng HANG Xing-Yi and ZHANG Cheng-Gang |
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| Institution: | Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850, China;Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850, China;Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850, China;Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850, China |
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| Abstract: | Dual coding is a phenomenon which refers to a mature mRNA that contains two open reading frames (ORFs) in the same direction to code two different proteins. This phenomenon is quite common in prokaryote, bacteriophages and viruses as an economical and effective way to present the genome information. However, recent reports suggest that the dual coding phenomenon does also occur in eukaryote. Dual coding will help us to further understand the complicated regulation of eukaryotic genes or even the law of molecular evolution. |
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| Keywords: | dual coding gene open reading frame eukaryote |
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