偏头痛患者体感刺激下脑电信号的功能连接（英文）

目的 偏头痛是一种复杂的脑功能障碍性疾病，全球范围内患病率为14.4%。功能连接测量两个神经信号之间的统计学相互依赖性，不同的功能连接反映了大脑区域协同工作的不同模式。因此，研究不同脑区的功能连接对于理解偏头痛的病理生理机制具有十分重要的意义。以往基于脑电图对偏头痛患者脑功能连接的分析主要集中在视觉和疼痛刺激。本文尝试研究偏头痛患者在发作间期对体感刺激的皮质反应，以进一步了解偏头痛的神经功能障碍，为偏头痛的预防和治疗提供线索。方法 招募23例无先兆偏头痛患者，10例有先兆偏头痛患者，28名健康对照者。所有受试者均进行详细的基本资料和病史采集，完善量表评估，在正中神经体感刺激下进行脑电图记录。计算68个脑区的相干性作为功能连接，并评估功能连接与临床参数的相关性。结果 在正中神经体感刺激下，无先兆偏头痛和有先兆偏头痛患者的脑电功能连接与对照组相比存在差异，异常的脑电功能连接主要位于感觉辨别、疼痛调节、情绪认知和视觉处理等区域。无先兆偏头痛和有先兆偏头痛患者的大脑皮层对体感刺激可能具有相同的反应方式。偏头痛患者的功能连接异常与临床特征之间存在相关性，可以部分反映偏头痛的严重程度。结论 本研究...

Research: Functional Connectivity of Electroencephalographic Signals in Migraine Under Somatosensory Stimulation

Objective Migraine is a complex brain dysfunction disease with a prevalence of 14.4% worldwide. Functional connectivity measures the statistical interdependences between two neural signals, and different functional connectivity patterns reflect different models of how brain regions work together. Therefore, investigating functional connectivity between different brain regions is important for understanding the pathophysiological mechanisms of migraine. Previous electroencephalogram-based functional connectivity analyses in migraine patients have mainly focused on visual and painful stimulation. We sought to investigate cortical responses to somatosensory stimulation in migraine patients during the interictal period, with the aims of better understanding the neurological dysfunction in migraine and providing clues for the prevention and treatment of migraine.Methods Twenty-three patients with migraine without aura, 10 patients with migraine with aura, and 28 healthy controls were recruited. Detailed basic data and medical history were collected from all participants, and the scale assessment was completed. All participants underwent electroencephalogram recording under median nerve somatosensory stimulation. The coherence of 68 brain regions was calculated as functional connectivity and correlations with clinical parameters were evaluated.Results Functional connectivity in migraine without aura and migraine with aura patients is atypical compared to controls under median nerve somatosensory stimulation, and the abnormal functional connectivity mainly involves areas of sensory discrimination, pain modulation, emotional cognition, and visual processing. The cerebral cortex in migraine without aura and migraine with aura patients may possess a common way of responding to somatosensory stimulation. The functional connectivity abnormalities in migraine patients have correlations with clinical features and may partly reflect the severity of migraine.Conclusion Our results provide evidence of altered functional connectivity in migraine patients under somatosensory stimulation, and suggest that the dysfunction in the brain network may be involved in the pathological process of migraine.