循环肿瘤细胞捕获与检测的纳米分析技术进展

随着纳米科学技术的发展,结构可控、表面多功能化、生物相容性良好的纳米材料在生物医药领域的各个方面都具有广泛的应用.作为一种重要的血液生物学标志物,循环肿瘤细胞(CTC)是肿瘤转移的"种子",活力较强的肿瘤细胞随着血液的流动可穿出血管在远端聚集形成微小的癌栓,对CTC的检测可用于癌症的早期诊断和转移的评估.新型纳米材料以及纳米表征测量技术的应用对CTC分析技术的进步产生了巨大的影响.近年来,基于纳米材料和微流控技术对CTC的捕获和检测已成为液体活检的研究热点,这一技术也被逐步推广到临床应用中.本文对纳米材料与纳米技术在CTC的捕获和检测中所发挥的作用进行了综述,并展望了该领域生物分析的应用前景.

Advances in Analytic Nanotechniques for The Capture and Detection of Circulating Tumor Cells

With the development of nanotechnology, nanomaterials with controllable structure, multifunctional surface and good biocompatibility have been widely used in various aspects of biomedicine. As an important blood biomarker, circulating tumor cells (CTC) are the "seeds" of tumor metastasis. With the flow of blood, tumor cells with strong vitality can pass through blood vessels and gather at the distal end to form tiny tumor thrombi. Therefore, the detection of CTC can be used for early diagnosis of cancer and assessment of metastasis. The application of new nanomaterials and nanomaterial characterization measurement technology has a great impact on the progress of CTC analysis technology. In recent years, the capture and detection of CTC based on nanomaterials and microfluidic technology has become a research hotspot in liquid biopsy, and this technology has been gradually extended to clinical applications. This article reviews the role of nanomaterials and nanotechnology in the capture and detection of CTC, and looks forward to the application prospects of bioanalysis in this field.