| 钙稳态失衡与癌细胞抑制 |
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| 引用本文： | 孙恩杰,闫玉华,徐运华.钙稳态失衡与癌细胞抑制[J].生物化学与生物物理进展,2001,28(5):635-638. |
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| 作者姓名： | 孙恩杰 闫玉华 徐运华 |
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| 作者单位： | 武汉理工大学理学院武汉430070 |
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| 基金项目： | 国家自然科学基金资助项目(39770225). |
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| 摘 要： | 细胞胞浆钙离子浓度必须处于严格的调控之中，钙稳态失调必将导致细胞严重损伤或死亡（凋亡或坏死）.综述了钙稳态失调在外界因素引起细胞死亡中的作用、直接钙稳态失调的细胞死亡效应、以及钙离子在细胞凋亡中的作用，并讨论了上述作用的机制，最后在总结基础上提出了一种抑癌新途径——选择性引发癌细胞钙稳态失衡.
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| 关 键 词： | 钙离子，钙稳态，细胞凋亡，癌细胞抑制 |
| 收稿时间： | 2000/11/27 0:00:00 |
| 修稿时间： | 2000年11月27 |
Disequilibrium of Calcium Homeostasis and Inhibition of Cancer Cell |
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| SUN En-Jie,YAN Yu-Hua and XU Yun-Hua.Disequilibrium of Calcium Homeostasis and Inhibition of Cancer Cell[J].Progress In Biochemistry and Biophysics,2001,28(5):635-638. |
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| Authors: | SUN En-Jie YAN Yu-Hua and XU Yun-Hua |
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| Institution: | College of Scinece, Wuhan University of Technology, Wuhan 430070, China;College of Scinece, Wuhan University of Technology, Wuhan 430070, China;College of Scinece, Wuhan University of Technology, Wuhan 430070, China |
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| Abstract: | The concentration of calcium ion in cytoplasm is in strict control. Disequilibrium of calcium homeostasis will result in severe injury even death of cells. The roles of such disequilibrium in cells death resulted from exogenous factors, evidences of direct lethal effect of the disequilibrium on cell and effects of calcium ion in apoptosis were reviewedd. Mechanisms of these effects were discussed. In the end, on the basis of summary, a new way to inhibit cancer cell was suggested, by inducing disorder of calcium homeostasis selectively in cancer cells. |
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| Keywords: | calcium ion calcium homeostasis apoptosis inhibition of cancer cell |
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