| 脑源性神经营养因子与抑郁症的研究进展 |
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| 引用本文： | 周小江,胡园,刘屏.脑源性神经营养因子与抑郁症的研究进展[J].生物化学与生物物理进展,2011,38(12):1085-1090. |
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| 作者姓名： | 周小江 胡园 刘屏 |
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| 作者单位： | 中国人民解放军总医院临床药理研究室，北京 100853;中国人民解放军总医院临床药理研究室，北京 100853;中国人民解放军总医院临床药理研究室，北京 100853 |
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| 基金项目： | 国家自然基金资助项目(30973891) |
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| 摘 要： | 脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是人体内含量最多的神经营养因子,在神经系统的发育和功能维持中起至关重要的作用.研究表明,抗抑郁剂通过提高BDNF表达来促进神经细胞的生存,增加突触可塑性及神经发生.
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| 关 键 词： | 抑郁症 脑源性神经营养因子(BDNF) 海马 酪氨酸激酶受体B(TrkB) |
| 收稿时间： | 3/1/2011 12:00:00 AM |
| 修稿时间： | 2011/5/23 0:00:00 |
Advances in Relationship Between Brain-derived Neurotrophic Factor and Depressive Disorder |
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| ZHOU Xiao-Jiang,HU Yuan and LIU Ping.Advances in Relationship Between Brain-derived Neurotrophic Factor and Depressive Disorder[J].Progress In Biochemistry and Biophysics,2011,38(12):1085-1090. |
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| Authors: | ZHOU Xiao-Jiang HU Yuan and LIU Ping |
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| Institution: | Department of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China;Department of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China;Department of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China |
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| Abstract: | Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system (CNS), serving many biological functions such as neural survival, differentiation, and plasticity. Treating the antidepressant drug could promote nerve cell survival and increase the synaptic plasticity and neurogenesis by improving BDNF expression. |
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| Keywords: | depression BDNF hippocampus TrkB |
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