肌球蛋白工作循环的一个新模型

分析总结关于分子马达肌球蛋白的最新研究结果，给出一个新的肌球蛋白工作循环的机械化学偶联模型.从新模型出发，用一组化学动力学方程描述肌肉中大量肌球蛋白的集体工作行为.利用动力学方程的非平衡定态解，并结合Pate和Cooke的实验结果得到了力作为变量的肌肉态方程.理论结果同热力学原理一致，与传统的肌肉收缩理论有一定区别.根据肌肉的特殊结构，对肌肉态方程做了进一步讨论.

A New Model of The Mechanochemical Actin-activated Myosin ATPase Cycle

A new model of the mechanochemical actin-activated myosin ATPase cycle is proposed. In active muscle, the collective behavior of a large number of myosins in muscle can be described with a set of chemical kinetic equations. The non-equilibrium steady state solution of equations shows that the fraction of myosin heads in any given biochemical state is independent of both the concentrations of ADP and Pi. Combining muscle mechanics data of Pate and Cooke, the muscle state equation is deduced. The theoretical results are consistent with Baker's experimental data but some what different from conventional muscle theory. Based on the knowledge of special structure of muscle, the muscle state equation is discussed thoroughly.