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病原菌调节宿主细胞丝裂原活化蛋白激酶免疫防御信号的机理
引用本文:葛建宁,邵峰.病原菌调节宿主细胞丝裂原活化蛋白激酶免疫防御信号的机理[J].生物化学与生物物理进展,2007,34(9):906-914.
作者姓名:葛建宁  邵峰
作者单位:中国协和医科大学研究生院,北京生命科学研究所,北京,102206
摘    要:丝裂原活化蛋白激酶(MAPK)家族广泛存在于高等生物中,介导多种生物学进程,在固有免疫防御中发挥重要作用,是真核细胞抵御病原菌侵染的第一道防线.越来越多的研究发现,病原菌可以利用多种方式激活或者抑制MAPK信号通路来增强其自身侵染力.简单介绍了MAPK信号通路的背景并详细总结了近几年关于病原菌如何作用于MAPK信号通路的研究工作,希望以此能够拓展对病原菌与宿主细胞作用方式的认识,深化对MAPK重要作用的了解.

关 键 词:丝裂原活化蛋白激酶(MAPK)  固有免疫  病原菌
收稿时间:2007/5/17 0:00:00
修稿时间:7/6/2007 12:00:00 AM

Hijacking The Eukaryotic MAPK Pathway by Pathogens
GE Jian-Ning and SHAO Feng.Hijacking The Eukaryotic MAPK Pathway by Pathogens[J].Progress In Biochemistry and Biophysics,2007,34(9):906-914.
Authors:GE Jian-Ning and SHAO Feng
Institution:Graduate School of Peking Union Medical College, National Institute of Biological Sciences, Beijing 102206, China;Graduate School of Peking Union Medical College, National Institute of Biological Sciences, Beijing 102206, China
Abstract:MAPK(mitogen-activated protein kinase) family,which is conserved throughout high eukaryotes,is implicated in multiple cellular processes including cell growth,migration,proliferation,differentiation,survival and development.Pathogen hijacks hosts' MAPK pathways to facilitate its pathogenesis using diverse strategies.To further explore the mechanism underlying interactions between pathogens and hosts' MAPK pathway,is of benefit to our understanding of nature as well as to our fight against pathogen infection.
Keywords:mitogen-activated protein kinase(MAPK)  innate immunity  pathogen
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