| 细胞提取物重编程研究进展 |
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| 引用本文： | 刘雨潇,张志文,傅相平,金鹏,李安民,张毅.细胞提取物重编程研究进展[J].生物化学与生物物理进展,2011(11). |
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| 作者姓名： | 刘雨潇 张志文 傅相平 金鹏 李安民 张毅 |
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| 作者单位： | 解放军总医院第一附属医院神经外科;军事医学科学院基础医学研究所; |
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| 基金项目： | 国家重点基础研究发展计划资助项目(2010CB833604); 国家自然科学基金面上项目(31070996)~~ |
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| 摘 要： | 体细胞重编程是在特定的条件下使已分化的细胞转变成为另一种细胞.体细胞重编程的方式主要有体细胞核移植技术、细胞融合技术、细胞提取物处理技术及特定转录因子转染技术.现有研究表明,细胞提取物重编程技术在体细胞重编程中发挥着一定的作用,为此,就该技术的最新研究进展和可能机制作一综述.
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| 关 键 词： | 细胞提取物 重编程 转分化 |
Cell Reprogramming by Cell Extract Treatment |
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| LIU Yu-Xiao,ZHANG Zhi-Wen,FU Xiang-Ping,JIN Peng,LI An-Min,ZHANG Yi.Cell Reprogramming by Cell Extract Treatment[J].Progress In Biochemistry and Biophysics,2011(11). |
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| Authors: | LIU Yu-Xiao ZHANG Zhi-Wen FU Xiang-Ping JIN Peng LI An-Min ZHANG Yi |
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| Institution: | LIU Yu-Xiao1),ZHANG Zhi-Wen1),FU Xiang-Ping1),JIN Peng2),LI An-Min1),ZHANG Yi2)(The First Affiliated Hospital of PLA General Hospital,Beijing 100037,China,Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | Cellular reprogramming described a switch of one kind of cell to that of another unrelated cell type by specific methods,which included mammalian somatic cell nuclear transfer,cell fusion,induction of pluripotency by ectopic gene expression,and cell-free extract treatment.Now,more and more researches have proved that cell extract treatment is an important strategy of cellular reprogramming,thus the mechanism and the applicative prospect of this technology are summarized in this review. |
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| Keywords: | reprogramming cellular extract transdifferentiation |
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