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拟南芥基因密码子偏爱性分析
引用本文:范三红,郭蔼光,单丽伟,胡小平.拟南芥基因密码子偏爱性分析[J].生物化学与生物物理进展,2003,30(2):221-225.
作者姓名:范三红  郭蔼光  单丽伟  胡小平
作者单位:西北农林科技大学,陕西省农业分子生物学重点实验室,杨凌,712100
摘    要:密码子偏爱性对外源基因的表达强度有一定影响,特别是编码蛋白质N端7~8个氨基酸残基的密码子.通过对拟南芥染色体中26 827个蛋白质对应的基因密码子进行分析,得到了编码氨基酸的61种密码子在拟南芥中的使用频率,并与大肠杆菌和哺乳动物进行了比较,结果表明三者间的密码子偏爱性有较大差异.这一分析结果对于动物基因在植物中的表达,及植物基因在微生物中的表达具有一定指导意义.同时提供了一种直接以XML文档为数据源解析巨型XML格式染色体数据的方法.

关 键 词:拟南芥,密码子偏爱性,XML
收稿时间:2002/8/12 0:00:00
修稿时间:2002年8月12日

Analysis of Genetic Code Preference in Arabidopsis thaliana
FAN San-Hong,GUO Ai-Guang,SHAN Li-Wei and HU Xiao-Ping.Analysis of Genetic Code Preference in Arabidopsis thaliana[J].Progress In Biochemistry and Biophysics,2003,30(2):221-225.
Authors:FAN San-Hong  GUO Ai-Guang  SHAN Li-Wei and HU Xiao-Ping
Institution:Northwest Sci-Tech University of Agriculture and Forestry, Key Laboratory of Agricultural Molecular Biology in Shaanxi Province, Yangling 712100, China;Northwest Sci-Tech University of Agriculture and Forestry, Key Laboratory of Agricultural Molecular Biology in Shaanxi Province, Yangling 712100, China;Northwest Sci-Tech University of Agriculture and Forestry, Key Laboratory of Agricultural Molecular Biology in Shaanxi Province, Yangling 712100, China;Northwest Sci-Tech University of Agriculture and Forestry, Key Laboratory of Agricultural Molecular Biology in Shaanxi Province, Yangling 712100, China
Abstract:The frequency of codon usage often affects the expression of foreign gene in transgenic research. A statistics of the frequency of codon usage in Arabidopsis thaliana was made, and a direct comparison of genctic code preference among Arabidopsis thaliana, Homo sapiens and Escherichia coli was carried out.The results show that Arabidopsis thaliana like Homo sapiens its frequency of codon usage is obviously different from Escherichia coli, and there is a considerable difference between Arabidopsis thaliana and Homo sapiens. The data will give some suggestions to those researchers who want to introduce a animal gene into plant or a plant gene into bacteria.
Keywords:Arabidopsis thaliana  code preference  XML
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