肿瘤靶向治疗的新型细胞载体

肿瘤靶向性病毒作为一种特殊的肿瘤治疗药物和基因治疗载体近年来已得到长足发展,许多高效、靶向性病毒载体已被相继研究开发,但仍不能满足临床上肿瘤靶向治疗的需要,如何将这些靶向病毒准确而高效地运输到肿瘤病变部位仍然未得到充分解决.细胞因子诱导杀伤细胞(cytokine-inducedkillercells,CIK)作为肿瘤的细胞治疗方法之一已成功地在临床上得到了广泛应用.最近科学家使用CIK细胞作为病毒运载工具,成功地将病毒运载到肿瘤组织部位并显示出高效的抗肿瘤作用,该方法为病毒运输定位于肿瘤病变部位找到了突破口,实验资料显示其具有潜在的应用价值.

A New-typed Cell Vehicle for Tumor Targeting Therapy

With a persisting development in tumor targeting viruses as a special anti-tumor agent and therapeutic gene vector for the recent years, a number of highly effective, targeting virus vectors have been exploited, which still did not satisfy the requirement for cancer targeting therapy in clinic. However, it has remained unsolved in how to effectively and veraciously deliver these targeting viruses to the tumor tissues. The cytokine-induced killer cells (CIK) as one of the cell therapy methods in tumor therapy have been widely applied in clinic. Recently, scientists have used the CIK cell as a vehicle to successfully carry viruses to the tumor tissues, which showed a robust anti-tumor effect. Meanwhile, the experiment method made a great breakthrough in systemic virus delivery and data figured a potential application for the treatment of cancers.