| 核糖体RNA拓扑学与RNA N－糖苷酶研究进展（上） |
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| 引用本文： | 张劲松,刘望夷.核糖体RNA拓扑学与RNA N－糖苷酶研究进展（上）[J].生物化学与生物物理进展,1994,21(1):23-27. |
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| 作者姓名： | 张劲松 刘望夷 |
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| 作者单位： | 中国科学院上海生物化学研究所;中国科学院上海生物化学研究所 |
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| 摘 要： | 核糖体RNA拓扑学的研究对阐明核糖体RNA(rRNA)在蛋白质生物合成中的作用具有重要的意义.RNA N-糖苷酶是一类核糖体失活蛋白.它只水解rRNA特定位置上一个腺苷酸的糖苷键,释放一个腺嘌呤碱基,使核糖体失活.Ricin A链是研究得最早和最详细的RNA N-糖苷酶,迄今已发现有二十五种核糖体失活蛋白具有RNA N-糖苷酶活性.RNA N-糖苷酶作用于28S rRNA的α-sarcin结构域,改变核糖体的构象而使其失活.
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| 关 键 词： | 核糖体拓扑学 核糖体失活蛋白 RNA N－糖苷酶 天花粉蛋白 |
| 收稿时间： | 1992/8/17 0:00:00 |
| 修稿时间： | 1992/12/8 0:00:00 |
Progress in Topography of Ribosomal RNA and RNA N-Glycosidase Research |
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| Zhang Jinsong and Liu Wangyi.Progress in Topography of Ribosomal RNA and RNA N-Glycosidase Research[J].Progress In Biochemistry and Biophysics,1994,21(1):23-27. |
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| Authors: | Zhang Jinsong and Liu Wangyi |
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| Institution: | Shanghai Institute of Biochemistry, Academia Sinica;Shanghai Institute of Biochemistry, Academia Sinica |
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| Abstract: | Studies on ribosomal RNA topography play an important role toward elucidation of the functional roles of rRNAs in protein synthesis.RNA N-glycosidases are a group of ribosome-inactivating proteins which inactivate ribosomes by hydrolyzing the N-C glycosidic bond of a special adenylic acid in rRNA and releasing the adenine. Ricin A-chain is the first determined RNA Nglycosidase which has been studied in the greatest detail. UP to the present. 25 glycosidases have been characterized. The action site of RNA N-glycosidases lies in the a-sarcin domain of 28S rRNA. Treatment of RNA N-glycosidases induces conformational change of ribosomes and leads to the inactivation. |
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