| BH3分析技术研究进展及其应用 |
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| 引用本文： | 袁静,曾妲,蒋小艳,周艳宏,肖松舒.BH3分析技术研究进展及其应用[J].生物化学与生物物理进展,2019,46(12):1179-1186. |
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| 作者姓名： | 袁静 曾妲 蒋小艳 周艳宏 肖松舒 |
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| 作者单位： | 1)中南大学湘雅三医院妇科，长沙 410013,1)中南大学湘雅三医院妇科，长沙 410013,1)中南大学湘雅三医院妇科，长沙 410013,2)中南大学基础医学院肿瘤研究所，长沙 410011,1)中南大学湘雅三医院妇科，长沙 410013 |
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| 基金项目： | 湖南省自然科学基金(2018JJ3782)，长沙市科技局项目（kq1701085,kq1701087）和中南大学研究生自主探索创新项目(2018zzts937,2018zzts952,2019zzts1055)资助. |
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| 摘 要： | 许多化疗药物发挥作用的重要方式是通过诱导线粒体介导的细胞凋亡.细胞凋亡在维持正常机体的内环境稳态中有重要作用,而在肿瘤细胞中,细胞凋亡的失调成为肿瘤细胞逃避化疗药物杀灭细胞作用的一道屏障. BCL-2家族蛋白在调节线粒体诱导的凋亡中处于中心地位,因此一项基于BCL-2家族蛋白的检测技术,BH3分析技术应运而生.该项技术的提出或许能为肿瘤的个性化治疗提供新的思路.本文重点综述BH3分析技术的原理,以及在肿瘤化疗药物选择和新型化疗药物开发中的应用.
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| 关 键 词： | BH3分析技术 肿瘤 化疗耐药 BCL-2蛋白家族 |
| 收稿时间： | 2019/7/28 0:00:00 |
| 修稿时间： | 2019/10/21 0:00:00 |
Research Progress and Application of BH3-profiling |
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| YUAN Jing,ZENG D,JIANG Xiao-Yan,ZHOU Yan-Hong and XIAO Song-Shu.Research Progress and Application of BH3-profiling[J].Progress In Biochemistry and Biophysics,2019,46(12):1179-1186. |
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| Authors: | YUAN Jing ZENG D JIANG Xiao-Yan ZHOU Yan-Hong and XIAO Song-Shu |
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| Institution: | 1)The Third Xiangya Hospital of Central South University, Changsha 410013, China,1)The Third Xiangya Hospital of Central South University, Changsha 410013, China,1)The Third Xiangya Hospital of Central South University, Changsha 410013, China,2)Cancer Research Institute, Basic School of Medicine, Central South University, Changsha 410011, China,1)The Third Xiangya Hospital of Central South University, Changsha 410013, China |
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| Abstract: | Mitochondrial-mediated apoptosis plays an important role for chemotherapeutic drugs in inducing cancer cell death,which also helps maintain homeostasis of the internal environment in normal organisms. In cancer cells, the dysregulation of apoptosis becomes a barrier for cancer cells to escape from the killing effect of chemotherapeutic drugs. In regulating mitochondrial-induced apoptosis, BCL-2 family proteins are of great importance. Therefore, a detection technology based on BCL-2 family proteins, BH3-profiling technology emerged. The proposed technology may provide new ideas for the personalized treatment of cancer. This paper focuses on the principle of BH3-profiling technology, its application in the selection of cancer chemotherapeutic drugs and the development of new chemotherapeutic drugs. |
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| Keywords: | BH3-profiling tumor chemoresistance BCL-2 family proteins |
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