| Syntaxin-1通过激活突触递质传递加速早期突触的形成 |
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| 引用本文： | 裴青,林寅,荣伊,刘孟雪,吴世平,阳小飞.Syntaxin-1通过激活突触递质传递加速早期突触的形成[J].生物化学与生物物理进展,2020,47(7):626-633. |
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| 作者姓名： | 裴青 林寅 荣伊 刘孟雪 吴世平 阳小飞 |
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| 作者单位： | 认知科学重点实验室，湖北省医学信息分析与肿瘤诊疗重点实验室，膜离子通道与药物研发实验室，中南民族大学生物医学工程学院，中国，武汉,认知科学重点实验室，湖北省医学信息分析与肿瘤诊疗重点实验室，膜离子通道与药物研发实验室，中南民族大学生物医学工程学院，中国，武汉,认知科学重点实验室，湖北省医学信息分析与肿瘤诊疗重点实验室，膜离子通道与药物研发实验室，中南民族大学生物医学工程学院，中国，武汉,认知科学重点实验室，湖北省医学信息分析与肿瘤诊疗重点实验室，膜离子通道与药物研发实验室，中南民族大学生物医学工程学院，中国，武汉,认知科学重点实验室，湖北省医学信息分析与肿瘤诊疗重点实验室，膜离子通道与药物研发实验室，中南民族大学生物医学工程学院，中国，武汉,认知科学重点实验室，湖北省医学信息分析与肿瘤诊疗重点实验室，膜离子通道与药物研发实验室，中南民族大学生物医学工程学院，中国，武汉 |
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| 基金项目： | 国家自然科学基金（31670850）和中南民族大学基础研究基金（CZY19022和CZY19040） |
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| 摘 要： | Syntaxin-1是一种多结构域蛋白,通过与synaptobrevin-2和SNAP-25形成SNARE复合体调节囊泡融合.然而,syntaxin-1在突触形成过程中是否发挥作用,目前尚不清楚.本研究显示syntaxin-1的表达水平与突触形成过程高度相关.Syntaxin-1的R151A和I155A突变影响其在突触形成中的促进作用,而Habc结构域或跨膜结构域在突触形成中无显著作用.结果表明,syntaxin-1通过激活突触囊泡释放来加速突触的形成.
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| 关 键 词： | syntaxin-1 突触形成 突触囊泡 动作电位触发的胞吐作用 |
| 收稿时间： | 2019/11/27 0:00:00 |
| 修稿时间： | 2020/6/2 0:00:00 |
Syntaxin-1 accelerates early synapse formation via activating synaptic transmission |
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| Pei Qing,Lin Yin,Rong Yi,Liu Meng-Xue,Wu Shi-Ping and Yang Xiao-Fei.Syntaxin-1 accelerates early synapse formation via activating synaptic transmission[J].Progress In Biochemistry and Biophysics,2020,47(7):626-633. |
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| Authors: | Pei Qing Lin Yin Rong Yi Liu Meng-Xue Wu Shi-Ping and Yang Xiao-Fei |
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| Institution: | Key Laboratory of Cognitive Science,Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis Treatment,Laboratory of Membrane Ion Channels and Medicine,College of Biomedical Engineering,South-Central University for Nationalities,Wuhan,China,Key Laboratory of Cognitive Science,Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis Treatment,Laboratory of Membrane Ion Channels and Medicine,College of Biomedical Engineering,South-Central University for Nationalities,Wuhan,China,Key Laboratory of Cognitive Science,Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis Treatment,Laboratory of Membrane Ion Channels and Medicine,College of Biomedical Engineering,South-Central University for Nationalities,Wuhan,China,Key Laboratory of Cognitive Science,Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis Treatment,Laboratory of Membrane Ion Channels and Medicine,College of Biomedical Engineering,South-Central University for Nationalities,Wuhan,China,Key Laboratory of Cognitive Science,Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis Treatment,Laboratory of Membrane Ion Channels and Medicine,College of Biomedical Engineering,South-Central University for Nationalities,Wuhan,China,Key Laboratory of Cognitive Science,Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis Treatment,Laboratory of Membrane Ion Channels and Medicine,College of Biomedical Engineering,South-Central University for Nationalities,Wuhan,China |
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| Abstract: | Syntaxin-1, known as a multi-domain protein, regulates vesicle fusion by forming SNARE complex with synaptobrevin-2 and SNAP-25. However, the role of syntaxin-1 in synapse formation remains uncovered. Here we demonstrated that the expression level of syntaxin-1 was highly associated with the process of synaptogenesis. The R151A and I155A mutations but not Habc or transmembrane domain truncations of syntaxin-1 impaired its facilitation in synapse formation. Our results suggested that syntaxin-1 accelerated synapse formation via activating synaptic vesicle release. |
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| Keywords: | syntaxin-1 synapse formation synaptic vesicle action potential triggered exocytosis |
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