| 血小板生成素及其研究进展 |
| |
| 引用本文： | 刘存仁,张红卫.血小板生成素及其研究进展[J].生物化学与生物物理进展,1996,23(4):290-293. |
| |
| 作者姓名： | 刘存仁 张红卫 |
| |
| 作者单位： | 山东大学生物系;山东大学生物系 |
| |
| 基金项目： | 山东大学青年自然科学基金资助项目. |
| |
| 摘 要： | 血小板生成素(TPO)是最近被描述的一种新型细胞因子,相对分子质量在35×103以上,是一种糖蛋白.人和鼠TPO成熟蛋白分别由332和335个氨基酸残基组成.TPO的受体与造血生长因子受体超家族成员c-Mpl相关.TPO不仅对巨核系祖细胞的增殖、分化具有明显的调控作用,而巨对血小板的生成同样具有促进作用.
|
| 关 键 词： | 血小板生成素 细胞因子 调控 |
| 收稿时间： | 7/3/1995 12:00:00 AM |
| 修稿时间： | 1995/9/27 0:00:00 |
Progress on the Study of Thrombopoietin |
| |
| Liu Cunren and Zhang Hongwei.Progress on the Study of Thrombopoietin[J].Progress In Biochemistry and Biophysics,1996,23(4):290-293. |
| |
| Authors: | Liu Cunren and Zhang Hongwei |
| |
| Institution: | Department of Biology, Shandong University;Department of Biology, Shandong University |
| |
| Abstract: | Thrombopoietin (TPO) is a recently described novel cytokine produced in both liver and kidney. TPO protein secreted is glycoprotein with relative molecular mass of over 35 ku.Human and mouse mature TPO consist of 332 and 335 amino acid residues respectively. TPO receptor is related to c-Mpl which is a member of the hematopoietin receptor superfamily. TPO not only regulates the proliferation and differentiation of megakaryocyte progenitor cells, but also regulates the production of platelets. |
| |
| Keywords: | thrombopoietin cytokine regulation |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
