生长因子及细胞因子的两条重要信号转导通路

业已发现的大部分生长因子受体具有酪氨酸激酶活性，其信号传递以Ras通路为主；而多数细胞因子受体本身缺乏酪氨酸激酶活性，其信号传递过程通过JAKs及STATs两个重要的蛋白质家族的介导得以实现．信号转导通路的研究，对于认识各种生长因子及细胞因子的作用机制具有重要意义．

Two Key Signal Transduction Pathways of Growth Factors and Cytokines

The Ras and JAKs-STATs signaling pathways after growth factors and cytokines activating their receptors respectively are briefly reviewed. The signal transduction of most growth factors' receptors with intrinsic tyrosine kinase activities is achieved through Ras protein pathway.Otherwise, members of JAKs and STATs superfamilies mediate the signaling process of cytokines' receptors lacking intrinsic tyrosine kinase activities. Studies on the signal transduction of growth factors and cytokines are becoming the important subjects in researches of life sciences.