| 黄芪有效成分对氧自由基清除作用的ESR研究 |
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| 引用本文： | 汪德清,沈文梅,田亚平,孙仲怡,丛建波,吴可.黄芪有效成分对氧自由基清除作用的ESR研究[J].生物化学与生物物理进展,1996,23(3):260-262. |
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| 作者姓名： | 汪德清 沈文梅 田亚平 孙仲怡 丛建波 吴可 |
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| 作者单位： | 解放军总医院生化科;解放军总医院生化科;解放军总医院生化科;军事医学科学院放射医学研究所;军事医学科学院放射医学研究所;军事医学科学院放射医学研究所 |
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| 摘 要： | 用电子自旋共振技术研究了黄芪总黄酮(TFA)、黄芪总皂甙(TSA)和黄芪总多糖(TPA)对次黄嘌呤／黄嘌呤氧化酶体系产生的超氧阴离子自由基和H2O2－Fe2+体系产生的羟自由基的清除作用．结果表明，这3种成分均有清除氧自由基的作用；对超氧阴离子自由基的清除效能大于对羟自由基的清除作用；其作用强度依次为TFA＞TSA＞TPA．结果提示清除氧自由基可能是黄芪抗衰老的主要机理之一，TFA和TSA是黄芪抗氧化作用的主要药理活性成分．
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| 关 键 词： | 黄芪 电子自旋共振 氧自由基 |
| 收稿时间： | 1995/7/26 0:00:00 |
| 修稿时间： | 1995/10/9 0:00:00 |
Scavenging Effects of Active Principles from Astragalus mongholicus Bunge on Oxygen Free Radicals Studied by ESR |
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| Wang Deqing,Shen Wenmei,Tian Yaping,Sun Zhongyi,Cong Jianbo and Wu Ke.Scavenging Effects of Active Principles from Astragalus mongholicus Bunge on Oxygen Free Radicals Studied by ESR[J].Progress In Biochemistry and Biophysics,1996,23(3):260-262. |
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| Authors: | Wang Deqing Shen Wenmei Tian Yaping Sun Zhongyi Cong Jianbo and Wu Ke |
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| Institution: | Department of Biochemsitry, General Hospital of PLA;Department of Biochemsitry, General Hospital of PLA;Department of Biochemsitry, General Hospital of PLA;Institute of Radiation Medicine, Academy of Military Medical Sciences;Institute of Radiation Medicine, Academy of Military Medical Sciences;Institute of Radiation Medicine, Academy of Military Medical Sciences |
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| Abstract: | Scavenging effects of total flavonoids of Astragalus (TFA), total saponins of Astragalus (TSA) and total polysaccharide of Astragalus (TPA) on superoxide anion radical and hydroxyl radical have been studied by ESR method. The results showed that all the three principles have stronger scavenging effect on superoxide anion radical than on hydroxyl radical. The intensity of scavenging effect of the three principles was TFA>TSA>TPA. It is suggested that the TFA and TSA are the main component in Astragalus mongholicus Bunge for protection against free radical damages. |
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| Keywords: | Astragalus mongholicus Bunge ESR oxygen free radical |
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