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从超氧化物歧化酶的分布和结构看其分子进化
引用本文:陈淮杨,刘望夷.从超氧化物歧化酶的分布和结构看其分子进化[J].生物化学与生物物理进展,1996,23(5):408-413.
作者姓名:陈淮杨  刘望夷
作者单位:中国科学院上海生物化学研究所;中国科学院上海生物化学研究所
摘    要:超氧化物歧化酶(SOD)是一种催化超氧化物阴离子自由基发生歧化反应, 生成氧和过氧化氢的金属酶. 按其结合的金属离子, 区分为Fe-SOD, Mn-SOD和CuZn-SOD三种. Fe-SOD主要存在于原核细胞中;Mn-SOD在原核和真核细胞中都存在;CuZn-SOD主要存在于真核细胞中. Fe, Mn-SOD的一级结构, 空间结构及其性质很相似, 来自一个共同的祖先; CuZn-SOD的结构与前两者相差较大, 是在以后的发展中单独进化的.

关 键 词:超氧化物歧化酶    分布    一级结构    空间结构    分子进化
收稿时间:1995/10/26 0:00:00
修稿时间:3/5/1996 12:00:00 AM

The Molecular Evolution of Superoxide Dismutase Based on its Distribution and Structure
Chen Huaiyang and Liu Wangyi.The Molecular Evolution of Superoxide Dismutase Based on its Distribution and Structure[J].Progress In Biochemistry and Biophysics,1996,23(5):408-413.
Authors:Chen Huaiyang and Liu Wangyi
Institution:Shanghai institute of Biochemistry, Academia Sinica;Shanghai institute of Biochemistry, Academia Sinica
Abstract:Superoxide dismutases (SODs) are metal-containing enzymes that catalyze the dismutation of superoxide radicals to oxygen and hydrogen peroxide. Three classes of SODs,Fe-SOD, Mn-SOD and CuZn-SOD, have been distinguished according to their bound metals.The Fe-SOD is essentially a prokaryotic enzyme,while the CuZn-SOD is essentially an eukaryotic enzyme. The Mn-SOD is present in both prokaryotes and eukaryotes. The Fe- and MnSODs appear to highly similar in the primary structure, three-dimensional structure and other physiochemical properties, but have no resemblance to CuZn-SOD. The Fe- and Mn-SOD can be traced to a common ancestor, whereas CuZn-SOD has evolved independently at a later time.
Keywords:superoxide dismutases    distribution    primary structure    three-dimensional structure    molecular evolution
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