| 纳米通道技术及应用 |
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| 引用本文： | 贾帅争,孙红琰,王全立.纳米通道技术及应用[J].生物化学与生物物理进展,2002,29(2):202-205. |
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| 作者姓名： | 贾帅争 孙红琰 王全立 |
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| 作者单位： | 北京输血医学研究所,北京,100850 |
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| 摘 要： | 纳米通道技术是近年来发展的一种直接解读核酸分子编码信息的新方法，它通过将单链核酸上的核苷酸序列直接转化为电信号，能以每秒超过1 000个碱基的速度对其进行超快速序列分析，较现有测序方法更简便快速和省钱.该技术除可用于核酸超快速外，还在病原体基因诊断、单核苷酸多态性和样品多成分的快速检测等多个领域有重要用途.
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| 关 键 词： | 纳米通道，α溶血素，核酸测序，传感器 |
| 收稿时间： | 2001/8/15 0:00:00 |
| 修稿时间： | 2001年8月15日 |
Nanopore Technology and Its Applications |
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| JIA Shuai-Zheng,SUN Hong-Yan and WANG Quan-Li.Nanopore Technology and Its Applications[J].Progress In Biochemistry and Biophysics,2002,29(2):202-205. |
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| Authors: | JIA Shuai-Zheng SUN Hong-Yan and WANG Quan-Li |
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| Institution: | Institute of Transfusion Medicine, Beijing 100850, China;Institute of Transfusion Medicine, Beijing 100850, China;Institute of Transfusion Medicine, Beijing 100850, China |
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| Abstract: | Nanopore technology is a new method developed in recent years to directly decipher genetic information of nucleic acids. It can sequence more than 1 000 bases per second by converting strings of nucleotides directly into electronic signatures. Nanopore sequencing is more quickly, easily and cost-effectively than existing technologies. Besides prospects for nucleic acids ultrarapid sequencing, this technology can also be used for gene diagnosis of pathogen, detection of single nucletide polymorphisms, rapid, stimultaneous multianalyte detection and other areas. |
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