| 基质力学对肿瘤发生发展及肿瘤细胞生物学行为影响的研究进展 |
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| 引用本文： | 张小梅,吕永钢,徐志玲,杨 力.基质力学对肿瘤发生发展及肿瘤细胞生物学行为影响的研究进展[J].生物化学与生物物理进展,2014,41(6):532-541. |
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| 作者姓名： | 张小梅 吕永钢 徐志玲 杨 力 |
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| 作者单位： | 生物流变科学与技术教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044；重庆大学生物工程学院国家“111计划”基地，重庆 400044,生物流变科学与技术教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044；重庆大学生物工程学院国家“111计划”基地，重庆 400044,生物流变科学与技术教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044；重庆大学生物工程学院国家“111计划”基地，重庆 400044,生物流变科学与技术教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044；重庆大学生物工程学院国家“111计划”基地，重庆 400044 |
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| 基金项目： | 新世纪优秀人才支持计划(NCET-10-0879)，国家自然科学基金(11172338)，中央高校基本科研业务费专项资金 (CDJZR 12238801, CQDXWL-2012-Z001)，教育部留学回国人员科研启动基金(教外司留[2001]508)和重庆大学大型仪器设备开放基金资助项目 |
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| 摘 要： | 实体瘤的发生发展常伴随着细胞外基质的异常沉积、交联和基质刚度增加.基质刚度增加和肿瘤细胞软化引起肿瘤微环境的力学异质性.基质力学通过影响肿瘤细胞的增殖、迁移、转移、上皮间质转换、肿瘤干细胞特性和耐药性等调控肿瘤的发生、恶性转变和转移.研究基质力学对肿瘤发生发展的影响不仅可深化对肿瘤发展的认识,也可为研究新的诊治方法提供理论基础.本文论述了细胞外基质力学特性对肿瘤发生发展及肿瘤细胞生物学行为影响的研究进展,并展望了其发展前景.
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| 关 键 词： | 基质力学 肿瘤发展 增殖和迁移 肿瘤转移 上皮间质转化 耐药性 |
| 收稿时间： | 2013/7/15 0:00:00 |
| 修稿时间： | 2013/11/19 0:00:00 |
Research Advances in The Effect of Matrix Mechanics on Tumor Development and Tumor Cell Biological Behavior |
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| ZHANG Xiao-Mei,LV Yong-Gang,XU Zhi-Ling and YANG Li.Research Advances in The Effect of Matrix Mechanics on Tumor Development and Tumor Cell Biological Behavior[J].Progress In Biochemistry and Biophysics,2014,41(6):532-541. |
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| Authors: | ZHANG Xiao-Mei LV Yong-Gang XU Zhi-Ling and YANG Li |
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| Institution: | Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;'111' Project Laboratory of Biomechanics and Tissue Repair, Bioengineering College, Chongqing University, Chongqing 400044, China,Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;'111' Project Laboratory of Biomechanics and Tissue Repair, Bioengineering College, Chongqing University, Chongqing 400044, China,Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;'111' Project Laboratory of Biomechanics and Tissue Repair, Bioengineering College, Chongqing University, Chongqing 400044, China and Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;'111' Project Laboratory of Biomechanics and Tissue Repair, Bioengineering College, Chongqing University, Chongqing 400044, China |
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| Abstract: | The development of solid tumor is often accompanied by extracellular matrix abnormal deposition, cross-linking and stiffening. Extracellular matrix stiffening and tumor cell softening contribute to the mechanical heterogeneity of tumor microenvironment. Matrix mechanics regulates tumorigenesis, malignancy, metastasis of tumor by affecting tumor cells proliferation, migration, epithelial-mesenchymal transition, properties of cancer stem cells and drug resistance. To study the effect of matrix mechanics on cancer development can not only deepen the understanding of cancer development, but also provide theoretical basis for developing new treatment strategy. In this paper, the research advances in the effect of extracellular matrix mechanical characteristics on tumor development and tumor cell biological behavior was summarized and its development prospect was also discussed. |
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